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Completed

NCT Number: NCT01509742

Effect of Liraglutide on Glucagon Secretion in Subjects With Type 2 Diabetes

This trial is conducted in Europe. The aim of this trial is to examine the effect of NNC 90-1170 on the hypoglycaemic counterregulation in subjects with type 2 diabetes.

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Key information

Conditions

Diabetes Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

30 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Novo Nordisk Investigational Site

Bad Lauterberg im Harz, 37431, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

age: minimum 30, maximum 75 years

Treatment and study plan

liraglutide

Drug

Single dose of 7.5 mcg/kg, injected subcutaneously followed by a hypoglycaemic clamp by concentration measurement

Other names: NNC 90-1170

Placebo

Drug

Single dose injected subcutaneously followed by a hypoglycaemic clamp by concentration measurement

Primary outcomes

  1. Area under the Curve (AUC) glucagon

Secondary outcomes

  1. Insulin secretion

  2. Glucose

  3. Cortisol

  4. Growth hormone

  5. Adrenaline

  6. Noradrenaline

  7. Adverse events

Sponsors and collaborators

Lead sponsor

Novo Nordisk A/S

Industry

Registry information

Official study title

Effect of NNC 90-1170 on Hypoglycaemic Counterregulation During Stepwise Hypoglycaemic Clamp in Type 2 Diabetic Subjects. A Double-blind, Placebo-controlled, Randomised, 2-period Cross-over Trial

Important dates

Study start
2001
Primary completion
2001
Study completion
2001
First posted
Jan 13, 2012
Registry last updated
Feb 1, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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