Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy

Purpose: There are some controversies about the effect of Levodopa-Carbidopa on treatment of non-arteritic anterior ischemic optic neuropathy (NAION). This study was performed to evaluate the effect of Levodopa-Carbidopa on visual acuity, color vision, and visual field in patients with recent onset NAION (less than 6 weeks duration).

Patients and Methods: In this double-blind randomized clinical trial, 13 patients were treated with levodopa-carbidopa and 12 patients took placebo for 3 weeks. Visual acuity, color vision, and visual field were tested before and at 4th, 12th, 16th, and 24th weeks after enrollment, and evaluated.

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Key information

Conditions

Nonarteritic Anterior Ischemic Optic Neuropathy Cardiovascular Diseases Cranial Nerve Diseases Eye Diseases Nervous System Diseases Optic Nerve Diseases Optic Neuropathy, Ischemic Vascular Diseases

Age range

50 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Ophthalmic research center

Tehran, Tehran Province, 1666694516, Iran

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age greater than 50 years old
first ophthalmic examination within 6 weeks after onset of disease
presence of optic disc swelling followed by optic atrophy within 6 weeks
altitudinal, central or generalized visual field defect
normal ESR

Exclusion criteria

confirmed giant cell arteritis
history of any ocular surgeries
optic neuropathy due to acute bleeding
advanced diabetic retinopathy
uncontrolled glaucoma
any ocular disorders that cause visual acuity reduction rather than NAION

Treatment and study plan

Levodopa-Carbidopa

Drug

Sponsors and collaborators

Lead sponsor

Shahid Beheshti University of Medical Sciences

Other

Registry information

Important dates

Study start: 2002
Study completion: 2003
First posted: Feb 7, 2007
Registry last updated: Oct 20, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed