Effect of Lactobacillus Rhamnosus on Serum Uremic Toxins in Hemodialysis

Uremic toxins such as p-cresol and phenol are suggested to be associated with higher mortality in hemodialysis patients. The aim of this study was to investigate the effects of probiotics on serum p-cresol level in hemodialysis patients.

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Key information

Conditions

Hemodialysis Complication

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Overall, 42 hemodialysis patients (10 women and 32 men) were divided randomly into the Lactobacillus rhamnosus group (21 patients) and the placebo group (21 patients).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

• Age more than 20 years

Acceptable performance of alimentary system
Ability to drink at least 200 ml of water per day
No history of being allergic to fungi and yeast
Absence of acute medical illness
life expectancy more than 3 months
Accept and sign the consent

Exclusion criteria

Patient's unwillingness to participate in the study
History of smoking, peritoneal dialysis (PD) or previous kidney transplantation
Lactation or pregnancy
Drug history including antibiotics, prebiotics, probiotics, herbal drugs, psychedelic drugs, flavors.

Treatment and study plan

Lactobacillus rhamnosus

Dietary Supplement

daily one capsule containing 1.6*107 CFU of Lactobacillus Rhamnosus prepared by Tabriz Nutrition Research Center from yogurt and cheese of different farms located in the suburbs Heris, after meal for 28 days

Placebo - Cap

Drug

daily one capsule of placebo

Other names: placebo

Primary outcomes

pre- and post-treatment p-cresol levels

Time frame: 4 weeks

Sponsors and collaborators

Lead sponsor

nooshin dalili

Other

Registry information

Official study title

Effect of Lactobacillus Rhamnosus on Serum Uremic Toxins (Phenol and P-Cresol ) in Hemodialysis Patients: A Double Blind Randomized Clinical Trial

Important dates

Study start: 2016
Primary completion: 2016
Study completion: 2016
First posted: May 17, 2018
Registry last updated: May 17, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed