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NCT Number: NCT07604948

Effect of Ischemic Preconditioning on Lower Extremity Motor Ability and Recovery in Basketball Players During Post-Match Recovery Period

This study aimed to evaluate the effects of ischemic preconditioning on lower limb explosive power and post-exercise recovery in basketball players during a 6-week post-season recovery training period. Thirty-four male collegiate basketball players were randomly assigned to either an IPC group or a placebo control group. Bilateral lower limb IPC intervention (3 cycles, each consisting of 5-minute ischemia at 220 mmHg and 5-minute reperfusion, twice per week for 6 weeks) was administered before routine basketball training sessions. Lower limb explosive power, as well as physiological, biochemical, and morphological indices, were assessed before and after the intervention.

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Key information

Age range

18 year–25 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Guangzhou Sport University

Guangzhou, Guangdong, 510430, China

Location status: Recruiting

Location contact

Ziyue Ou, PHD

CONTACT

[email protected]

15626121623

About this study

Background: Lower limb explosive power is crucial for basketball performance, and effective recovery strategies are key to maintaining training quality. Ischemic preconditioning (IPC) is a non-invasive, economical, and safe method that triggers endogenous protective mechanisms through brief ischemia-reperfusion cycles, showing potential in enhancing athletic performance and metabolic efficiency. However, the effects of IPC on lower limb explosive power during post-match recovery in basketball players remain understudied. Objective: To investigate the effects of a 6-week repeated remote ischemic preconditioning on lower limb explosive power, phosphagen energy system capacity, and physical recovery in male college basketball players. Design: A randomized, parallel-group, placebo-controlled trial with concealed allocation. Participants were randomly assigned to either the IPC experimental group (n=17) or the placebo control group (n=17). Both groups participated in the same regular basketball sessions. The experimental group received bilateral thigh IPC intervention (3×5 minutes, 220 mmHg) before each training session, while the control group received a placebo intervention (3×5 minutes, 20 mmHg). The intervention was administered twice a week for 6 weeks (30 minutes per session). Secondary endpoints: Urinary creatinine coefficient, 10-second maximal load test (blood lactate increment, peak power, mean power), hematological parameters (red blood cell count, hemoglobin, hematocrit, white blood cell count), serum testosterone, cortisol, testosterone/cortisol ratio, body composition (body weight, body fat percentage, BMI), and training load monitoring (heart rate, RPE, urine protein).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male basketball students at Guangzhou Sport University.
  • Regular participants in basketball training/practice.
  • Healthy adults without cardiovascular, hepatic, renal, digestive, neurological, or metabolic diseases.
  • Blood pressure within normal range.
  • No history of lower extremity musculoskeletal injury within the past 6 months.
  • Not currently using any performance-enhancing substances or medications affecting hormones/metabolism.
  • Voluntary participation with signed informed consent.

Exclusion criteria

  • Presence of acute or chronic diseases affecting exercise performance.
  • History of deep vein thrombosis or coagulation disorders.
  • Presence of skin lesions or infections at the thigh cuff placement site.
  • Participation in other concurrent lower extremity strength/power training programs outside the study.
  • Use of dietary supplements known to affect muscle metabolism within 4 weeks prior to enrollment.
  • Inability to complete the full 6-week intervention and testing protocol.

Treatment and study plan

Ischemic Preconditioning

Device

Bilateral thigh compression was applied using a Theratools pneumatic cuff (T-bfr-0475). Three cycles, each consisting of 5 minutes of ischemia (pressure 220 mmHg) and 5 minutes of reperfusion (total 30 minutes), were performed before regular basketball training sessions. The intervention was conducted twice per week for 6 weeks. Cuff placement: at the inguinal crease of the thigh. Subject position: supine, alternating between left and right legs.

Placebo Ischemic Preconditioning

Device

Identical procedure to IPC group except cuff pressure maintained at 20 mmHg (non-ischemic), applied before regular basketball training. Twice weekly for 6 weeks.

Primary outcomes

  1. Squat Jump (SJ) height

    Time frame: Baseline (Week 0) and Post-intervention (Week 8)

    Change from baseline in lower extremity concentric explosive power measured by Smart Jump portable contact mat (cm).

  2. Countermovement Jump (CMJ) height

    Time frame: Baseline and Week 8

    Change from baseline in lower extremity reactive explosive power without arm swing (cm).

  3. Reactive Strength Index (RSI)

    Time frame: Baseline and Week 8

    Change from baseline in RSI derived from 30cm drop jump using Smart Jump system (m/s). The RSI was calculated as jump height divided by ground contact time, with higher values indicating better reactive strength capacity in athletes (i.e., shorter ground contact times and greater jump heights). The observed range of RSI in the present study was [minimum value]-[maximum value] m/s.

  4. Standing Long Jump

    Time frame: Baseline and Week 8

    Change from baseline in lower extremity horizontal explosive power (cm).

  5. T-Test (T-run)

    Time frame: Baseline and Week 8

    Change from baseline in multi-directional agility performance (seconds).

  6. 3/4 Court Sprint

    Time frame: Baseline and Week 8

    Change from baseline in linear sprint speed over 3/4 basketball court distance (~21m, seconds).

Secondary outcomes

  1. Blood Lactate Accumulation

    Time frame: Baseline and Week 8

    Change in blood lactate accumulation during 10-second maximal load test (mmol/L).

  2. Peak Power (10s Test)

    Time frame: Baseline and Week 8

    Change from baseline in peak power output during 10-second maximal load test on Monark 828E cycle ergometer (Watts).

  3. Mean Power (10s Test)

    Time frame: Baseline and Week 8

    Change from baseline in mean power output during 10-second maximal load test (Watts).

  4. Testosterone/Cortisol Ratio

    Time frame: Baseline and Week 8

    Change from baseline in T/C ratio (×10-²).

Study contacts

Contact information is provided by the study sponsor or research team.

Ziyue Ou, PHD

CONTACT

[email protected]

+8615626121623

Sponsors and collaborators

Lead sponsor

Guangzhou Sport University

Other

Registry information

Official study title

Effect of Ischemic Preconditioning on Lower Extremity Motor Ability and Recovery in Basketball Players During Post-Match Recovery Period: A Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
May 22, 2026
Registry last updated
May 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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