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OpenTrials
Completed

NCT Number: NCT06964555

Effect of Intravenous Low-Dose Ketamine Infusion With Intravenous Lignocaine Infusion on Post-Operative Pain in Patients Undergoing Laparoscopic Choleysystectomy Under General Anesthesia

Objective: To determine the effect of low-dose ketamine versus lignocaine on post-operative pain in patients undergoing LC under general anesthesia in a tertiary care hospital.

Sample Selection: Patients of both the gender of age at least 18 years, planned for elective LC with ASA grade I-II were included. Patients with obesity, history of alcohol consumptions, drug abusers, uncontrolled hypertension and diabetics, with chronic pain, allergic to study drugs, having neurological disorders, unable to understand pain scoring system and converted to open LC were excluded.

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Key information

Conditions

Cholelithiases Biliary Tract Diseases Cholelithiasis Digestive System Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Fazaia Ruth Pfau Medical College

Karachi, Sindh, 75510, Pakistan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients of both the gender of age at least 18 years
  • Patients planned for elective LC
  • Patients with ASA grade I-II were included.

Exclusion criteria

  • Patients with obesity,
  • Patients with history of alcohol consumptions, uncontrolled hypertension and diabetics,
  • Drug abusers
  • Patients with chronic pain
  • Patients allergic to study drugs
  • Patients having neurological disorders or unable to understand pain scoring system
  • Patients converted to open LC

Treatment and study plan

Intravenous Ketamine Infusions

Drug

Ketamine group received ketamine at 0.2mg/kg bolus intravenously followed by ketamine infusion at rate of 0.2mg/kg/hr throughout the surgery.

Intravenous lignocaine

Drug

IV Lignocaine was given at the rate of 1 mg/kg/hr.

Primary outcomes

  1. Post operative Pain

    Time frame: 24 hours

    Pain was assessed using Numeric Rating Scale which is a ten point scoring scale ranging from 0-10 for ranking pain where 0 means no and 10 means worst pain.

Secondary outcomes

  1. Time to rescue analgesia

    Time frame: 24 hours

    Time to rescue analgesia was defined as time point at which patient will be given first rescue analgesia for pain of score more 5 or above.

  2. Wound Closure

    Time frame: End of Surgery

    The time between the incision and the wound's closure was used to define the length of the surgery.

Sponsors and collaborators

Lead sponsor

Fazaia Ruth Pfau Medical College

Other

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
May 9, 2025
Registry last updated
May 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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