Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis

The aim of this study is to compare parenteral ceftriaxone and oral doxycycline in the treatment of neuroborreliosis in a randomized controlled trial.

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Key information

Conditions

Lyme Neuroborreliosis Bacterial Infections Bacterial Infections and Mycoses Borrelia Infections Central Nervous System Bacterial Infections Central Nervous System Diseases Central Nervous System Infections Gram-Negative Bacterial Infections Infections Lyme Disease Nervous System Diseases Spirochaetales Infections Tick-Borne Diseases Vector Borne Diseases

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Sørlandet Sykehus HF

Kristiansand, Vest-Agder, 4633, Norway

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Neurological symptoms and/or findings consistent with neuroborreliosis and at least one of the following fulfilled:

Intrathecal production of borrelia antibodies;
White cell count in cerebrospinal fluid (CSF) > 5/mm3;
Significant rise in borrelia antibodies in two serum samples collected from a patient with at least 3 weeks interval;
Verified acrodermatitis chronica atrophicans.

Exclusion criteria

Allergy to the contents in the medication, or earlier type I reaction to penicillin.
Treatment with cephalosporins, penicillin or tetracyclins during the last 14 days
Pregnancy or breastfeeding
Age < 18 years

Treatment and study plan

Ceftriaxone

Drug

Doxycycline

Drug

Sponsors and collaborators

Lead sponsor

Sorlandet Hospital HF

Other Gov

Registry information

Official study title

Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis. A Randomized Double-blind Comparison

Important dates

Study start: 2004
Primary completion: 2008
Study completion: 2008
First posted: Aug 30, 2005
Registry last updated: May 6, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed