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Completed

NCT Number: NCT06319144

Effect of Intravenous 5% Dextrose Infusion During Recovery from Anesthesia on the Quality of Early Postoperative Recovery in Patients Undergoing Painless Gastrointestinal Endoscopy

The aim of this study was to determine the effect of intravenous infusion of 5% dextrose injection during the recovery period of anesthesia for painless gastroenteroscopy on the patient's blood glucose level, incidence of hypoglycemia and time of awakening from anesthesia, postoperative vertigo, postoperative nausea and vomiting, and quality of recovery in the early postoperative period.

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Key information

Conditions

Insulin Resistance Dizziness Dizzyness Glucose Metabolism Disorders Hyperinsulinism Metabolic Diseases Nausea Neurologic Manifestations Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Postoperative Nausea and Vomiting Quality of Recovery Sensation Disorders Signs and Symptoms Signs and Symptoms, Digestive Vomiting

Age range

18 year–79 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Lin Cheng

Weifang, Shandong, 261041, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients who meet the indications for painless gastrointestinal endoscopy and are aged 18 to 79 years.
  • The patient or his/her guardian or immediate family members gave informed consent;
  • American Society of Anesthesiology (ASA) anesthesia risk classification ≤ grade III.

Exclusion criteria

  • Patients with contraindications to sedation/anesthesia for gastrointestinal endoscopy: e.g., severe hepatic and renal dysfunction, cardiac insufficiency;
  • Patients receiving chemotherapy and opioid treatment; patients with a history of sleep apnea hypoventilation syndrome;
  • Intravenous nutritional support within 8 hours prior to the examination;
  • Patients diagnosed with type I or type II diabetes.

Treatment and study plan

5% glucose

Other

Patients in the experimental group were infused intravenously with 5% dextrose (500 ml/h) in the PACU.

Other names: 5% dextrose, 5% Glucose and sodium chloride injection

0.9% sodium chloride solution

Other

Patients in the control group were infused intravenously with 0.9% sodium chloride solution in the PACU.

Primary outcomes

  1. Preoperative blood glucose 30min

    Time frame: Measurements taken 0.5 hours Preoperative.

    A fingertip blood glucose concentration of <3.9 mmol/L was used as a diagnostic criterion for hypoglycemia. Severity and incidence of hypoglycemia at 0.5 hours Preoperative.

  2. Postoperative blood glucose 2h

    Time frame: Measured at 2 hours postoperatively.

    A fingertip blood glucose concentration of <3.9 mmol/L was used as a diagnostic criterion for hypoglycemia. Severity and incidence of hypoglycemia at 2 hours postoperatively.

  3. Dizziness level

    Time frame: Approximately 15min after surgery

    The Visual Analogue Scale(VAS) was used to assess the degree of postoperative dizziness in patients undergoing painless gastroenteroscopy.

  4. Dizziness level

    Time frame: Measured at 0.5 hours postoperatively.

    The visual analogue scale (VAS) was used to assess the degree of postoperative dizziness in patients undergoing painless gastroenteroscopy.

  5. Postoperative nausea and vomiting

    Time frame: Measured at 0.5 hours postoperatively.

    The Index of Nausea and Vomiting and Retching (INVR) was used in this study. The scale consists of 8 items with 3 dimensions, which can quantify the number of occurrences, duration and severity of symptoms. The scale is scored using the Likert method, with a total of 32 points on a 5-point scale ranging from 0 to 4. The higher the score, the more severe the symptoms of nausea, vomiting, and dry heaving (entries 1, 6, and 7 are reverse scored). According to the score, nausea, vomiting and dry heaving symptoms can be categorized into five grades: 0, I, II, III and IV, and grade ≥I means that the symptom occurs. The severity and incidence of PONV at 0.5 hours postoperatively.

  6. Postoperative nausea and vomiting

    Time frame: Measured at 2 hours postoperatively.

    The Index of Nausea and Vomiting and Retching (INVR) was used in this study. The scale consists of 8 items with 3 dimensions, which can quantify the number of occurrences, duration and severity of symptoms. The scale is scored using the Likert method, with a total of 32 points on a 5-point scale ranging from 0 to 4. The higher the score, the more severe the symptoms of nausea, vomiting, and dry heaving (entries 1, 6, and 7 are reverse scored). According to the score, nausea, vomiting and dry heaving symptoms can be categorized into five grades: 0, I, II, III and IV, and grade ≥I means that the symptom occurs. The severity and incidence of PONV at 0.5 hours postoperatively.

Secondary outcomes

  1. Anesthesia awakening time

    Time frame: Approximately 30min after surgery

    The clinical routine defines the time of awakening from anesthesia as the time between the cessation of anesthesia administration and the opening of the patient's eyes on call.

  2. Quality of postoperative recovery (QoR40)

    Time frame: Approximately 24hours after surgery

    The QoR-40 scale provides a true and valid reflection of the impact of various factors on the quality of postoperative recovery.

Sponsors and collaborators

Lead sponsor

Weifang Medical University

Other

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Mar 19, 2024
Registry last updated
Mar 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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