Skip to main content
OpenTrials
Completed

NCT Number: NCT06626542

Effect of Intra-session Exercise Modes Sequence on Ventricular Function in Patients With Chronic Heart Failure

The aim of this study was to investigate the effect of intra-session exercise modes sequence on ventricular function in patients with chronic heart failure.

Completed

Looking for future studies?

Notify Me

Key information

Age range

55 year–65 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

National Heart Institute

Giza, Agouza Giza Governorate, 12511, Egypt

About this study

Sixty male patients with chronic heart failure will be recruited in this study from National Heart Institute Giza, Egypt. Their ages will be ranged from 55 to 65 years old and they will be randomly divided into three groups as following:

  • Study group (A) includes 20 patients who will receive intra-session exercise modes sequence of aerobic cardiovascular training (CVT) then resistance training (RT) exercises in addition to routine treatment programme.
  • Study group (B) includes 20 patients who will receive intra-session exercise modes sequence of resistance training (RT) then aerobic cardiovascular training (CVT) exercises in addition to routine treatment programme.
  • Control group (C) includes 20 patients who will receive routine treatment programme only.

The exercise training programme for both study groups A and B will be applied once per day, three times per week for 12 consecutive weeks.

Inclusion criteria

All participated patients will be:

  • Male patients with chronic heart failure and ages from 55 to 65 years old.
  • Class II and class III heart failure according to NYHA classification.
  • HFrEF category with LVEF <40% as documented by echocardiogram within <6 months.
  • Receiving the same medical treatment programme for at least 3 months.
  • Having a close level of functional capacity assessed by 6 minute walking test.

Exclusion criteria

Patients who meet one of the following criteria will be excluded:

  • Uncontrolled atrial fibrillation.
  • Diabetes mellitus.
  • Myocardial infarction or recurrent angina within <3 months.
  • Patients with chronic chest diseases.
  • Severe stenotic valvular disease.
  • Clinically significant peripheral vascular disease.
  • Exercise-induced angina, ST segment changes or exercise induce AV block.
  • Patients with chronic renal failure.
  • Any cognitive impairment that interferes with prescribed exercise procedures.
  • Musculoskeletal or neurological limitation to physical exercise.

RESEARCH ETHICS

The protocol of this study will be approved by the ethics committee of scientific research at the Faculty of Physical Therapy, Cairo University. The study procedure will be explained in details for every patient before the initial assessment. All patients will be informed about the purpose, nature, and potential risks of the study, and a written informed consent will be obtained before participation in the study. The participants' right confidentiality will be observed strictly.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male patients with chronic heart failure and ages from 55 to 65 years old.
  • Class II and class III heart failure according to NYHA classification.
  • HFrEF category with LVEF <40% as documented by echocardiogram within <6 months.
  • Receiving the same medical treatment programme for at least 3 months.
  • Having a close level of functional capacity assessed by 6 minute walking test

Exclusion criteria

  • • Uncontrolled atrial fibrillation.
  • Diabetes mellitus.
  • Myocardial infarction or recurrent angina within <3 months.
  • Patients with chronic chest diseases.
  • Severe stenotic valvular disease.
  • Clinically significant peripheral vascular disease.
  • Exercise-induced angina, ST segment changes or exercise induce AV block.
  • Patients with chronic renal failure.
  • Any cognitive impairment that interferes with prescribed exercise procedures.
  • Musculoskeletal or neurological limitation to physical exercise.

Treatment and study plan

resistance and aerobic training exercises

Other

resistance and aerobic training exercises

Other names: cardiac rehabilitation

Primary outcomes

  1. Left ventricular ejection fraction

    Time frame: 12 weeks

    left ventricular ejection fraction is measured by using echocardiography it is measured in percentage %

Secondary outcomes

  1. The Minnesota living with heart failure questionnaire (MLWHFQ)

    Time frame: 12 weeks

    calculate minnasota living with heart failure questionnaire score 21 item MLHFQ uses a 6-point scale where 0 = no, 1= very little and 5= very much

  2. Cardiorespiratory fitness 6 minute walk test

    Time frame: 12 weeks

    after the test we calculate the distance patient walked in meters and we use this distance to evaluate the cardiopulmonary fitness

  3. Vo2 Max

    Time frame: 12 week

    by using distance from the 6MWT in meters we can calculate the vo2 max using specific equation

  4. Blood pressure

    Time frame: 12 weeks

    blood pressure systolic by using the sphygmomanometer palpatory method - diastolic by using the auscultatory method by sphygmomanometer and stethoscope

  5. Rate of pressure product

    Time frame: 12 week

    rate pressure product will be calculated by this equation : patient heart rate * systolic blood pressure / 1000

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

EFFECT OF INTRA-SESSION EXERCISE MODES SEQUENCE ON VENTRICULAR FUNCTION IN PATIENTS WITH CHRONIC HEART FAILUIRE

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Oct 4, 2024
Registry last updated
Jan 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.