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NCT Number: NCT07540481

Effect of Internal Jugular Vein Catheterization on Intracranial Pressure and Intracranial Blood Flow

This prospective observational study aims to evaluate the effect of internal jugular vein catheterization on intracranial pressure using optic nerve sheath diameter (ONSD) measurements and carotid artery Doppler ultrasonography in adult patients undergoing surgery under general anesthesia.

ONSD will be measured noninvasively using transorbital ultrasonography, and carotid Doppler parameters will be assessed at two time points: after endotracheal intubation and approximately 5 minutes after catheterization. The primary objective is to assess short-term changes in ONSD following catheterization.

Secondary objectives include evaluating changes in carotid Doppler measurements and their relationship with ONSD, as well as associations with physiological parameters such as blood pressure, heart rate, oxygen saturation, and end-tidal carbon dioxide.

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Key information

Conditions

Intracranial Pressure Ultrasonography

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

This prospective observational study is designed to investigate the effect of internal jugular vein catheterization on intracranial pressure using noninvasive ultrasonographic methods in adult patients undergoing elective surgery.

Internal jugular vein catheterization will be performed as part of routine clinical care in patients requiring central venous access. The study does not introduce any additional intervention beyond standard clinical practice.

Intracranial pressure will be indirectly assessed by measuring optic nerve sheath diameter (ONSD) using transorbital ultrasonography with a high-frequency linear probe. Measurements will be obtained at a standardized depth of 3 mm posterior to the optic disc.

In addition, carotid artery Doppler ultrasonography will be performed to assess hemodynamic parameters, including flow velocities and derived indices.

All ultrasonographic measurements will be performed at two predefined time points: after endotracheal intubation and approximately 5 minutes following internal jugular vein catheterization. Measurements will be obtained from the side of catheterization.

The primary outcome is the change in ONSD following internal jugular vein catheterization. Secondary outcomes include changes in carotid Doppler parameters and their relationship with ONSD, as well as associations with physiological variables such as blood pressure, heart rate, oxygen saturation, and end-tidal carbon dioxide.

Ultrasonographic assessments are noninvasive and considered safe, with no known risk to participants. All data will be collected prospectively and analyzed to evaluate short-term physiological changes associated with the procedure.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥18 years
  • Patients undergoing surgery under general anesthesia
  • Patients requiring internal jugular vein catheterization as part of routine clinical care
  • Ability to obtain optic nerve sheath diameter measurements using transorbital ultrasonography
  • Provision of informed consent

Exclusion criteria

  • Known intracranial pathology affecting intracranial pressure
  • Ocular conditions preventing accurate ultrasonographic measurement (e.g., orbital trauma, ocular surgery, infection)
  • Hemodynamic instability
  • Contraindication to internal jugular vein catheterization
  • Inability to obtain adequate ultrasound images

Treatment and study plan

Internal Jugular Vein Catheterization

Procedure

Internal jugular vein catheterization is performed in patients undergoing major surgical procedures when clinically indicated as part of routine perioperative care. The procedure is not assigned by the study. Additional non-invasive ultrasound measurements, including optic nerve sheath diameter assessment, are obtained to evaluate physiological changes associated with catheterization without altering standard clinical management. Ultrasonography is a non-invasive and safe imaging method routinely used in clinical practice.

Primary outcomes

  1. Change in Optic Nerve Sheath Diameter (mm) Following Internal Jugular Vein Catheterization

    Time frame: Baseline (immediately after endotracheal intubation) and 5 minutes after internal jugular vein catheterization

    Optic nerve sheath diameter (ONSD) will be measured in millimeters using transorbital ultrasonography at 3 mm posterior to the optic disc on the side of catheterization. The outcome is defined as the difference between measurements obtained immediately after endotracheal intubation (baseline) and 5 minutes after internal jugular vein catheterization. Higher values indicate increased optic nerve sheath diameter.

Secondary outcomes

  1. Change in Internal Carotid Artery Peak Systolic Velocity (PSV) Following Internal Jugular Vein Catheterization

    Time frame: Baseline (immediately after endotracheal intubation) and 5 minutes after internal jugular vein catheterization

    Peak systolic velocity (PSV) of the internal carotid artery will be measured in cm/s using Doppler ultrasonography. The outcome is defined as the difference between post-intubation (baseline) and post-catheterization values.

  2. Change in Internal Carotid Artery End-Diastolic Velocity (EDV) Following Internal Jugular Vein Catheterization

    Time frame: Baseline and 5 minutes after internal jugular vein catheterization

    End-diastolic velocity (EDV) of the internal carotid artery will be measured in cm/s using Doppler ultrasonography. The outcome is defined as the difference between post-intubation and post-catheterization values.

  3. Change in Internal Carotid Artery Time-Averaged Maximum Velocity (TAMAX) Following Internal Jugular Vein Catheterization

    Time frame: Baseline and 5 minutes after internal jugular vein catheterization

    Time-averaged maximum velocity (TAMAX) will be measured in cm/s using Doppler ultrasonography. The outcome is defined as the difference between post-intubation and post-catheterization values.

  4. Change in Internal Carotid Artery Pulsatility Index (PI) Following Internal Jugular Vein Catheterization

    Time frame: Baseline and 5 minutes after internal jugular vein catheterization

    Pulsatility index (PI) will be calculated from Doppler measurements (unitless). The outcome is defined as the difference between post-intubation and post-catheterization values.

  5. Change in Internal Carotid Artery Systolic/Diastolic Ratio (S/D) Following Internal Jugular Vein Catheterization

    Time frame: Baseline and 5 minutes after internal jugular vein catheterization

    The systolic/diastolic (S/D) ratio will be calculated from Doppler measurements (unitless). The outcome is defined as the difference between post-intubation and post-catheterization values.

  6. Change in Mean Arterial Pressure (MAP)

    Time frame: Baseline and 5 minutes after internal jugular vein catheterization

    Mean arterial pressure (MAP) will be measured in mmHg. The outcome is defined as the difference between post-intubation (baseline) and post-catheterization values.

  7. Change in Heart Rate

    Time frame: Baseline and 5 minutes after internal jugular vein catheterization

    Heart rate will be measured in beats per minute (bpm). The outcome is defined as the difference between post-intubation and post-catheterization values.

  8. Change in End-Tidal Carbon Dioxide (EtCO₂)

    Time frame: Baseline and 5 minutes after internal jugular vein catheterization

    End-tidal carbon dioxide (EtCO₂) will be measured in mmHg. The outcome is defined as the difference between post-intubation and post-catheterization values.

Study contacts

Contact information is provided by the study sponsor or research team.

Aysun Edehan, MD

CONTACT

[email protected]

+905309127017

Ayça Sultan Şahin, Prof. Dr.

CONTACT

[email protected]

+905323100840

Sponsors and collaborators

Lead sponsor

Kanuni Sultan Suleyman Training and Research Hospital

Other

Registry information

Official study title

Effect of Internal Jugular Vein Catheterization on Intracranial Pressure Assessed by Optic Nerve Sheath Diameter and Carotid Doppler Ultrasonography: a Prospective Observational Study

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Apr 20, 2026
Registry last updated
Apr 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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