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NCT Number: NCT07722260

Effect of Implementing Cough Augmentation Techniques on Weaning Outcomes Among Critically Ill Patients

The study aims to determine the effect of implementing cough augmentation techniques on weaning outcomes among critically ill patients

Recruiting

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Key information

Conditions

Physiological Parameters

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

Cough augmentation techniques are important interventions for critically ill patients who have impaired cough strength due to mechanical ventilation, neuromuscular weakness, sedation, or respiratory muscle dysfunction. These techniques, which include manual assisted cough, lung volume recruitment, and mechanical insufflation-exsufflation, enhance expiratory airflow and improve the clearance of airway secretions

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adult intubated patients
  • both sex

Exclusion criteria

  • patient with facial trauma
  • patient with tracheostomy tube

Treatment and study plan

cough augmentation techniques

Other

the lung volume recruitment maneuver via MV was applied with assistant of the attended physician as follows: Use pressure-controlled ventilation and increase end-inspiratory volume (30 or 40 cm H2O for 30 to 40 seconds unless contraindicated) or inspiratory hold for 30 to 40 seconds to promote cough effectiveness. The patient serially inhales a volume of gas without exhalation until maximum insufflation capacity via the ventilator to facilitate breath-holding (if not contraindicated).

Primary outcomes

  1. weaning success

    Time frame: within 7 days

    measured through successful extubating

Study contacts

Contact information is provided by the study sponsor or research team.

Alaa Mustafa, assistant professor

CONTACT

[email protected]

0201097210526

Heba Saad, lecturer

CONTACT

[email protected]

04501274855242

Sponsors and collaborators

Lead sponsor

[email protected]

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 23, 2026
Registry last updated
Jul 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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