Skip to main content
OpenTrials
Completed

NCT Number: NCT06373562

Effect of Hypoxic Exposure on Blood Variables in Elite Wrestlers

Twelve male wrestlers of the National Polish Team were observed in the study during the camp. The hypoxia group (n=6) participated in sports training and hypoxic exposure, while the control group (n=6) included wrestlers participating only in sports training. The hypoxic group lived and slept in hypoxic rooms. During the camp, all wrestlers followed the same training schedule and diet. In the blood were determined levels of creatine kinase (CK), C-reactive protein (hsCRP) concentration, nitric oxide (NO), morphology, reticulocytes, lipid profile, and ferritin. Also vascular endothelial growth factor (VEGF, VEGFR2, and VEGFR3), erythropoietin (EPO), angiopoietin (Ang 1, Ang 2), endothelial cell adhesion factor-1 (VCAM-1), Erythropoietin (EPO) and hypoxia-inducible factor 1 (HIF-1). Body weight composition was determined.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Hypoxia Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

About this study

Hypoxia exposure applied to professional athletes has attracted attention and scientific debate due to its effects on improving physiological response through cardiovascular and hematological mechanisms. Presently, hypoxic training programs are developed to improve exercise performance in athletes, a useful training method for athletes that may improve their performance in future sea-level competitions. 12 males were divided into the hypoxic (H) and control (C) groups. Group H was living and sleeping in hypoxic rooms (method live high-train low) for 8-14h/d (FiO2≈14%). The implementation of the project was intended to: 1) assess the dynamics of changes in the concentration of pro-inflammatory indicators and hematopoiesis in athletes to variable training loads and hypoxia, 2) explain the usefulness of hypoxic exposure in adaptation to physical exercise, 3) observe the length of the hypoxic cycle necessary to maintain the effect of high-altitude training. In the blood serum the level of basic biochemical indicators of fatigue related to muscle damage, inflammation, and energy deficit, i.e. total creatine kinase (CK) activity, C-reactive protein (hsCRP) concentration, nitric oxide (NO). Moreover, basic hematological indicators: morphology, reticulocytes, lipid profile, and ferritin. Also, angiogenesis regulators: vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFR2 and VEGFR3), erythropoietin (EPO), angiopoietin (Ang 1, Ang 2), endothelial cell adhesion factor-1 (VCAM-1), Erythropoietin (EPO) and hypoxia-inducible factor 1 (HIF-1). Body weight composition was determined using a body analyzer. Further investigations into hypoxia methods while considering individual capabilities are necessary for gaining deeper insights, into how hypoxia affects blood count and different blood variables among athletes.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • member of national wrestler's teams, and sports camp participant.

Exclusion criteria

  • negative symptoms of hypoxia, and/or injury.

Treatment and study plan

Hypoxia

Other

The athletes were living in hypoxic rooms, which could simulate a selected altitude above sea level.

Primary outcomes

  1. CK

    Time frame: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.

    creatine kinase

  2. hsCRP

    Time frame: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.

    reactive C-protein

  3. HIF-1

    Time frame: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.

    hypoxia-inducible factor 1

  4. EPO

    Time frame: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.

    Erythropoietin

  5. VEGF, VEGF 2, VEGF 3.

    Time frame: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.

    vascular endothelial growth factor

  6. Ang 1, Ang 2

    Time frame: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.

    angiopoietin

  7. VCAM-1

    Time frame: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.

    endothelial cell adhesion factor-1

Other outcomes

  1. blood count

    Time frame: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.

    morphology

  2. lipid profile

    Time frame: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.

    HDL, LDL, triglycerides

  3. ferritin

    Time frame: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.

    ferritin

Sponsors and collaborators

Lead sponsor

Poznan University of Physical Education

Other

Registry information

Official study title

The Influence of Sports and Hypoxic Training on the Regeneration and Adaptation of Skeletal Muscles to Exercise in Wrestlers.

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Apr 18, 2024
Registry last updated
Jan 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.