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NCT Number: NCT07547969

Effect of Hip Extension Mobilization on Functional Disability in Patients With Spondylolisthesis

this study will be conducted to investigate the effect of hip extension mobilization on lumber disability, pain and flexion range of motion in patients with spondylolisthesis

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Key information

Conditions

Spondylolisthesis Bone Diseases Musculoskeletal Diseases Spinal Diseases Spondylolysis Spondylosis

Age range

40 year–60 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

About this study

Spondylolisthesis is a kind of low back pain (LBP) that involves displacement of one vertebral body relative to the vertebra below it. Spondylolisthesis is derived from the Greek words spondylosis, which means vertebra, and olisthisis, which means slippage. The displacement of the cranial vertebra can be anterior (also known as anterolisthesis), lateral, or posterior (retrolisthesis) to the more caudal vertebra., most commonly occurring as an anterior slippage at the lumbosacral junction(L5-S1). The condition can result from several etiologies including congenital, isthmic, degenerative, traumatic, or pathologic causes. The clinical presentation of spondylolisthesis encompasses a broad spectrum, ranging from asymptomatic cases to those involving debilitating pain, neural compromise, and functional limitations. Degenerative spondylolisthesis (DS) predominantly affects older adults, with a marked predilection for females. A cross-sectional epidemiological survey involving over 4,000 patients reported a prevalence of 2.7% in men and 8.4% in women, underscoring a significant sex disparity.The most common site for degenerative spondylolisthesis is the L5 to S1 level. Mobilization increases hip range of motion, decreases pain and improves hip function more than non-weight bearing exercises.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Chronic female Patients diagnosed as grade 1 lumbar degenerative spondylolisthesis (anterolisthesis) referred from Orthopedists was confirmed by lumbosacral x-ray
  • Patients age ranged from 40 to 60 years.
  • BMI(25:35)
  • Ambulant patient with or without cane.
  • Cooperative patients with ability to understand instructions and follow simple verbal commands.

Exclusion criteria

  • Osteoporosis.
  • Pregnancy.
  • Signs consistent with nerve root compression (reproduction of low-back or leg pain with a straight leg raise at less than 45°, muscle weakness involving a major muscle group of the lower extremity, diminished lower extremity muscle stretch reflex, or diminished or absent sensation to pinprick in any lower extremity dermatome).
  • General tumors, spinal tumor, fracture, cauda equina syndrome, and previous surgery.
  • Other causes of spondylolisthesis.
  • Patients with (BMI ≥ 35)
  • Severe or life-threatening psychiatric illness.

Treatment and study plan

hip extension mobilization

Other

the patients will receive hip extension mobilization to increase hip extension range of motion; the therapist applies an anterior glide mobilization-usually with the patient in a prone position. The patient is positioned in prone at the edge of the table. The hip is then flexed, abducted, and externally rotated into position as tolerated by the patient, and the foot is placed next to the contralateral knee. Impart anterior mobilization through the greater trochanter. The therapist applies a grade IV mobilization in a posterior to anterior direction to target the anterior hip.

The mobilizing hand applies a downward ward force through an extended elbow; body weight exerts the force+ cinentional treatment

conventional treatment

Other

Each subject will be given treatment of 30-40 minute session of William flexion exercises. The seven variations of Williams's exercises include (Pelvic tilt, single knee to chest, double knee to chest, half sit-up, hamstring stretch, hip flexor stretches, and squat). in additionn, The TENS electrodes are typically placed bilaterally along the lumbar paraspinal region directly over the painful area. The frequency of the output was set at 4 to 8 Hz. Continuous type used.

Primary outcomes

  1. low back disability

    Time frame: up to four weeks

    Arabic version of Roland Morris Disability will be used to assess low back disability. it is a valid, reliable 24-item tool used to assess physical disability in patients with low back pain (LBP). It has been culturally adapted to Modern Standard Arabic, with a score ranging from 0 to 24, where higher scores indicate greater functional disability.

Secondary outcomes

  1. pain intensity

    Time frame: up to four weeks

    The visual analogie scale will be used to assess pain intensity. it is a one-dimensional instrument used to assess subjective pain intensity. It comprises a 10-cm (100-mm) line; with 0 refer to no pain while 100mm refer to extreme pain.

  2. lumbar flexion range of motion

    Time frame: up to four weeks

    The BROM device will be used for lumbar flexion ROM.

Study contacts

Contact information is provided by the study sponsor or research team.

Alaa Kazamel, master

CONTACT

[email protected]

01203016831

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Acronym: EM

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 23, 2026
Registry last updated
Apr 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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