Effect of High-intensity Laser Exercise Versus Moderate-intensity Aerobic Exercise on Diabetic Polyneuropathy Patients

Diabetic poly neuropathy (DPN) is a length-dependent, symmetrical sensorimotor poly neuropathy and is among the most prevalent and challenging consequences of diabetes4.

The documented prevalence of DPN varies between 13% and 55%, with 25% to 50% of these individuals experiencing neuropathic pain5. This study was conducted to find out the impact of high-intensity laser versus moderate-intensity aerobic exercises on diabetic poly neuropathy patients.

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Key information

Conditions

Diabetic Nephropathies Diabetes Complications Diabetes Mellitus Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Urogenital Diseases Urologic Diseases

Age range

30 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Soad

Minya, 05637, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Neuropathic symptoms in the lower limbs, including numbness, tingling, pain, burning, electric shock, and stabbing

Exclusion criteria

sensory polyneuropathy unrelated to diabetes as
systemic diseases,
infections,
inflammatory conditions,
drug effects,
metal exposure,
hereditary factors

Treatment and study plan

High-intensity laser (HIL)

Radiation

The wavelength measured 1064 nm, accompanied by a power output of 5.00 W. The frequency employed was 25 Hz

moderate-intensity aerobic exercise

Procedure

walking on a treadmill at a speed of 3-4 miles per hour on a flat surface (0% incline) for 40 minutes, 3 times weekly over eight weeks

Primary outcomes

Lower extremity functional performance

Time frame: 3 months

scale for both groups from 0 (minimum) to 80 (maximum)

Sponsors and collaborators

Lead sponsor

Deraya University

Other

Registry information

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Mar 19, 2025
Registry last updated: Sep 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed