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Completed

NCT Number: NCT01143363

Effect of High-intensity Intermittent Sprinting on Appetite Control on Obese Volunteers

Several studies have shown that high intensity intermittent sprints (HIIS) are more effective than moderate intensity continuous cycling (MICC) in reducing fat mass and improving insulin resistance in normal weight individuals. Changes in the appetite-regulatory system in response to exercise are likely to explain, at least partially, the better outcome observed after HIIS. Unfortunately, there are no studies comparing the impact of different types of acute aerobic exercise on the release of appetite-regulating hormones, subjective feelings of appetite and subsequent energy intake (EI).

The primary objective of this study is to investigate the effects of acute isocaloric bouts of HIIT and MICC or a short duration sprint, in comparison with a resting control condition, on the postprandial release of appetite-regulating hormones, subjective feelings of appetite and subsequent EI in obese individuals. The investigators hypothesize that an isocaloric session of HIIS will result in a better short-term appetite control compared with MICC, by reducing hunger feelings and subsequent food intake more than MICC and by inducing a larger increase in the release of satiety gut peptides compared with the MICC.

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Key information

Conditions

Obesity Behavior Body Weight Motor Activity Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Norwegian University of Science and Technology

Trondheim, 7489, Norway

About this study

This will be a randomised cross-over study with four legs. Participants will act as their own controls and will be assigned to the four experimental conditions (resting, HIIS, MICC and SDS), 1 week apart, in a counter-balanced order.

Participants will be asked to come to the Unit five times: one preliminary session and four experimental conditions (resting, HIIS and MICC isocaloric sessions and SDS). In the preliminary session, anthropometric data (weight and height) will be collected and a maximal fitness test performed, using a cycle ergometer.

For the four experimental conditions, participants will be asked to arrive at approximately 8.00, having fasted for at least 10 hours, and a cannula will be inserted into an antecubital vein. Two fasting blood samples will be taken and a standard breakfast offered. After that, serial blood samples will be taken at regular intervals for a period of 3h.

Participants will be asked to rate their subjective feelings of hunger and fullness using visual analogue scales (VAS) throughout each study morning at different time points. Three hours after breakfast, participants will be placed in individual rooms, presented with a standardized lunch and instructed to rate the taste and palatability of the food presented.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • an inactive lifestyle,
  • weight stable on the previous 3 months,
  • not currently dieting to loose weight
  • restraint score derived from the Three Factor Eating Behaviour Questionnaire ≤12

Exclusion criteria

  • history of coronary heart disease,
  • type 1 or type 2 diabetes,
  • anaemia,
  • gout,
  • depression or other psychological disorders,
  • eating disorders,
  • drug or alcohol abuse within the last two years,
  • current medication known to affect appetite or induce weight loss and hypertension.

Treatment and study plan

resting - control

Behavioral

Moderate Intensity Exercise

Behavioral

High intensity intermittent training

Behavioral

Short sprint

Behavioral

Primary outcomes

  1. Changes in gut peptides

    Time frame: Blood samples taken in fasting and postprandially for 3h

Secondary outcomes

  1. Food intake at test meal

    Time frame: 3h after breakfast

    Food intake at a test meal will be assessed 3h after breakfast (at 180 minutes)

Sponsors and collaborators

Lead sponsor

Norwegian University of Science and Technology

Other

Collaborators

  • Helse Midt-Norge

Registry information

Official study title

Acute Effects of High-intensity Intermittent Sprinting vs. Moderate Intensity Continuous Cycling on Appetite Control on Obese Volunteers

Important dates

Study start
2010
Primary completion
2012
Study completion
2014
First posted
Jun 14, 2010
Registry last updated
Feb 6, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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