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Completed

NCT Number: NCT01779245

Effect of High-calcium Intake on Substrate Metabolism During Exercise

A high-calcium intake can accelerate fat loss under energy-restricted diets. Part of this may be due to a shift in substrate metabolism where there is an increase in the rate of fat oxidation. However, whether high-calcium intake can influence substrate metabolism during exercise is not known. Accordingly, we aim to investigate the effect of 2 weeks of high-calcium intake on substrate metabolism during exercise.

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Key information

Conditions

Lipid Metabolism

Age range

18 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Northumbria University

Newcastle upon Tyne, Tyne and Wear, NE1 8ST, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Physically active (moderate-vigorous exercise >3 time per week)
  • Male
  • 18-40 yrs of age

Exclusion criteria

  • Smoker
  • Known Food Allergies
  • Metabolic disorders

Treatment and study plan

Calcium

Dietary Supplement

Milk-extracted calcium supplement will be used to modulate the calcium content of the milkshakes used.

Placebo

Dietary Supplement

Primary outcomes

  1. Substrate metabolism

    Time frame: 60 s samples every 3 min for 15 min

    Substrate metabolism will be assessed by the respiratory exchange ratio (rate of carbon dioxide production/rate of oxygen consumption) from samples of expired gas collected during the first 15 minutes of an incremental cycling test.

Secondary outcomes

  1. Plasma non-esterified fatty acid concentrations

    Time frame: Every 3 min for 15 min

    Non-esterified fatty acid concentrations will be determined from plasma samples collected during the first 15 minutes of an incremental cycling test to indicate fatty acid availability.

  2. Plasma glycerol concentrations

    Time frame: Every 3 min for 15 min

    Glycerol concentrations will be determined from plasma samples collected during the first 15 minutes of an incremental cycling test as a marker of lipolysis.

Other outcomes

  1. Serum parathyroid hormone concentration

    Time frame: Baseline (Pre-post 2 week supplementation)

    Parathyroid hormone concentrations will be determined at rest before and after supplementation periods as a indicator of calcium status.

  2. Plasma glucose-dependent insulinotropic peptide concentration

    Time frame: Baseline (Pre-post 2 week supplementation)

    Glucose-dependent insulinotropic peptide concentrations will be determined at rest before and after supplementation periods as a potential mechanism of any changes in metabolism.

  3. Plasma glucagon-like peptide-1 concentration

    Time frame: Baseline (Pre-post 2 week supplementation)

    Glucagon-like peptide-1 concentrations will be determined at rest before and after supplementation periods as a potential mechanism of any changes in metabolism.

Sponsors and collaborators

Lead sponsor

Northumbria University

Other

Registry information

Official study title

The Impact of a Calcium Supplementation on Lipid Metabolism During Exercise.

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Jan 30, 2013
Registry last updated
Sep 6, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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