Skip to main content
OpenTrials
Completed

NCT Number: NCT03871647

Effect of Genetic Polymorphism on the Occurrence of Post-Operative Atrial Fibrillation After CABG

Postoperative Atrial Fibrillation (POAF) is one of the most common complications following coronary artery bypass grafting (CABG) occurring to 20% - 40% of patients. It is associated with prolonged hospitalization, increased hospital costs, increased complications and mortality rate.

Despite the use of Beta Blockers, approximately 20% of patients develop atrial fibrillation following CABG surgery, suggesting a role for polymorphism in the genes The aim of the present study is to determine the minor allele frequency of some of the genes that affect the beta blockers' response and to determine the association between polymorphism in these genes and the occurrence of postoperative atrial fibrillation after coronary artery bypass grafting in Egyptian patients receiving perioperative beta blockers.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Coronary Bypass Graft Surgery Arrhythmias, Cardiac Atrial Fibrillation Cardiovascular Diseases Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The Cardiovascular & Thoracic Academy - Ain Shams University.

Cairo, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age above 18 years.
  • Candidates for CABG surgery without a concurrent valve surgery.
  • Patients receiving perioperative beta blockers before new onset of postoperative AF.

Exclusion criteria

  • Patients who have either persistent or permanent AF, atrial flutter or atrial tachycardia on ECG obtained on the day of the operation.
  • Serum creatinine >2 mg/dL before the surgery.
  • Uncontrolled thyroid disease.
  • Recent treatment with amiodarone before the occurrence of POAF

Treatment and study plan

Beta blocker

Drug

perioperative beta blockers

Primary outcomes

  1. Occurrence of Atrial fibrillation

    Time frame: within 6 days after the operation

    Atrial fibrillation based on postoperative electrocardiogram. AF diagnostic criteria will include absence of discrete P waves, the RR intervals follow unrepetitive form and the ranges of ventricular rate usually between 90 and 170 beats/min.

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Collaborators

  • Misr International University

Registry information

Official study title

Effect of Genetic Polymorphism on the Occurrence of Post-Operative Atrial Fibrillation After Coronory Artery Bypass Grafting (CABG) Surgery in Egyptian Patients Receiving Beta Blockers

Important dates

Study start
2019
Primary completion
2020
Study completion
2021
First posted
Mar 12, 2019
Registry last updated
Nov 9, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.