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Completed

NCT Number: NCT03818009

Effect of General Anesthesia on Early Postoperative Cognitive Function in Cesarean Section

Cognitive dysfunction is the impairment of the mental process of perception, memory and information processing. The preoperative cognitive state is important, as mild cognitive impairment may be worsened following a cesarean section. Our study will aim to assess the incidence of early cognitive dysfunction after elective and emergent cesarean section under general anesthesia.

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Key information

Conditions

Anesthesia Morbidity Cesarean Section Complications

Age range

25 year–35 year

Sex eligibility

Female

Study type

Observational

Primary location

Nesreen Abdel Fattah Abdullah Shehata

Cairo, Egypt

About this study

Mechanisms that lead to cognitive decline after anesthesia and surgery remain still unclear and mixed. Some studies suggested that an important role is played by the immune response to surgery. The inflammatory response could contribute to the development of postoperative cognitive decline (POCD0 through secretion of cortisol, cytokines, and other inflammatory mediators. Comparing the effects of general and spinal anesthesia on pregnant patients undergoing an elective cesarean section, found no cognitive change after both anesthesias. Our observational comparative study will be carried out at Beni Suef University Hospital. We will compare early cognitive functions undergoing general anesthesia in patients undergoing elective and emergency cesarean section.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women in reproductive age period between 25 and 35 years
  • Women booked for an elective or emergency cesarean section.

Exclusion criteria

  • Mental disorder preoperative
  • Medical conditions ( as Hypertension or diabetes or cardiac diseases)

Treatment and study plan

Assessment document

Other

The anesthesiologist will evaluate through his sheet women's cognitive functions.

Other names: Anesthesiologist evaluation sheet

Primary outcomes

  1. postoperative cognitive decline (POCD)

    Time frame: 3 hours postoperative

    New impairment of memory directly post operative which will be assessed by psychometric questionnaire

Secondary outcomes

  1. impaired performance on intellectual tasks

    Time frame: 3 days postoperative

    New impairment of using mind in daily tasks directly post operative which will be assessed through a questionnaire

Sponsors and collaborators

Lead sponsor

Beni-Suef University

Other

Registry information

Official study title

Effect of General Anesthesia on Early Postoperative Cognitive Dysfunction in Elective Versus Emergency Cesarean Section

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Jan 28, 2019
Registry last updated
Nov 17, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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