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Completed

NCT Number: NCT02960412

Effect of Furosemide on Confirmation of Ureteral Patency During Routine Cystoscopy

This study evaluates if administration of IV furosemide leads to expedited confirmation of ureteral patency when compared to placebo (IV saline) in routine cystoscopy performed after urogynecologic surgery.

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Key information

Conditions

Cystoscopy

Age range

18 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Tampa General Hospital

Tampa, Florida, 33606, United States

About this study

Cystoscopy is performed routinely after urogynecologic surgery to ensure there was no injury to the urinary tract (urethra, bladder, or ureters). In order to confirm that no damage occurred to the ureters, a jet of urine must be visualized from each ureteral opening.

The time it takes to confirm this ureteral patency is variable and some sources suggest using furosemide to decrease the time it takes to see these jets. This study will evaluate what effect, if any, this medicine has on time to confirming ureteral patency.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Undergoing any urogynecologic surgery
  • No allergy or contraindication to receiving furosemide
  • Normal Creatinine/glomerular filtration rate

Exclusion criteria

  • Unable to consent, including if non English speaking
  • Allergy or contraindication to receiving furosemide
  • Intraoperative injury to the lower urinary tract

Treatment and study plan

Furosemide

Drug

10mg lasix given intraoperatively

Other names: Lasix

normal saline

Drug

Normal saline given intraoperatively as placebo

Primary outcomes

  1. time to ureteral patency

    Time frame: intra-operative

    time to confirmation of ureteral patency in seconds

Secondary outcomes

  1. adverse effects from furosemide administration

    Time frame: immediately post operative (1-3 days post operatively)

Sponsors and collaborators

Lead sponsor

University of South Florida

Other

Registry information

Official study title

Randomized Controlled Trial Evaluating Effect of Furosemide on Confirmation of Ureteral Patency During Routine Cystoscopy

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Nov 9, 2016
Registry last updated
Mar 28, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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