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OpenTrials
Completed

NCT Number: NCT02717377

Effect of Frequent Interruptions of Prolonged Sitting on Self-perceived Levels of Energy, Mood, Food Cravings and Cognitive Function

This study is designed to test the effects of six 5 minute microbursts of physical activity spread across the day as compared to either a sedentary control condition or a single 30 minute bout of moderate intensity physical activity on cognitive function, self-reported energy levels, aspects of eating behavior and measures of metabolic health. The primary hypotheses are:

1. Hourly 5 minute bouts of moderate intensity exercise during the day will increase afternoon cognitive function as compared to a no exercise condition. 2. Hourly 5 minute bouts of moderate intensity exercise during the day will increase afternoon cognitive function more than a single 30 minute AM bout.

Secondary exploratory hypotheses include

1. Hourly 5 minute bouts of moderate intensity exercise during the day will increase self-reported energy levels, reduce orexigenic appetitive measures and improve measures of metabolic health as compared to a no exercise condition. 2. Hourly 5 minute bouts of moderate intensity exercise during the day will increase self-reported energy levels, reduce orexigenic appetitive measures and improve measures of metabolic health more than a single 30 minute AM bout.

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Key information

Age range

19 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All ethnic groups and both genders
  • Age: Lower age limit: 19 years; Upper age limit: 45 years
  • Body-mass Index: Lower BMI limit: 18.5 kg/m2; Upper BMI limit: 29.9 kg/m2
  • Willing to adhere to caffeine restrictions of no more than two 16 ounce beverages in the morning of each study day with no caffeine intake after 12:00pm on any of the three study days

Exclusion criteria

  • History of cardiovascular disease, including coronary artery disease, congestive heart failure, & unstable angina, or uncontrolled hypertension (>140/90 mm Hg)
  • Currently smoking or stopped smoking in the last 6 months
  • Medications affecting weight, energy intake, or energy expenditure in the last 6 months
  • Use of oral steroids
  • History of stroke or seizures, thyroid disease, type 1 or 2 diabetes, Cushing's syndrome, cerebrovascular, renal disease, hepatic disease, arrhythmias
  • Cancer requiring treatment in the past 5 years, with the exception of skin cancers other than melanoma
  • Infectious diseases: Self-reported HIV positivity or active tuberculosis
  • Inability to exercise for more than 30 minutes on a treadmill at moderate intensity
  • Currently pregnant, lactating or less than 6 months post-partum
  • History of a major psychiatric disorder including schizophrenia, bipolar illness or psychotic depression
  • Score of >25 on Beck Depression Inventory
  • No recreational drug use including marijuana in the past 1 year

Treatment and study plan

Physical activity

Behavioral

Primary outcomes

  1. Change in Energy and Mood level

    Time frame: During each of the three separate study days energy and mood levels are assessed at (in minutes): T0, T40, T70, T80, T90, T120, T140, T230, T350, T390, T400, T405, T410, and T435

    Self-perceived energy and mood were measured by using visual analogue scales (VAS) as described below at baseline.

  2. Change in Cognitive function

    Time frame: During each of the three separate study days cognitive function is measured at (in minutes): T410

    The flanker task is used to measure cognitive function

  3. Change in Cognitive Function

    Time frame: During each of the three separate study days cognitive function is measured at (in minutes): T425

    After the Flanker task, the Comprehensive Trail Making Test is used to measure cognitive function during each study day.

Sponsors and collaborators

Lead sponsor

University of Colorado, Denver

Other

Registry information

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Mar 23, 2016
Registry last updated
Mar 23, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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