Effect of Food on the Pharmacokinetics of ORIC-114

The study will be performed in two parts. Part 1 will assess the effect of food at a lower dose of ORIC-114 to first ascertain the degree of food effect (if any) on ORIC-114 exposure as a way to ensure the safety of the participating subjects. Part 2 will further assess the food effect at a higher dose of ORIC-114.

If the preliminary Part 1 results clearly show no food effect, Part 2 may not need to be conducted upon assessment by the Sponsor.

If Part 2 is conducted, the dose of ORIC-114 will be selected within the anticipated efficacious clinical dose range based on results from Part 1.

Inclusion criteria

• Healthy, adult, male or female (of nonchildbearing potential only), 18-55 years of age
• Continuous nonsmoker who has not used nicotine and tobacco containing products for at least 30 days
• Body mass index (BMI) ≥ 18.0 and ≤ 32.0 kg/m2
• Medically healthy with no clinically significant medical history, physical examination, laboratory profiles, vital signs, and ECGs, as deemed by the PI or designee
• Able to swallow multiple tablets.

Exclusion criteria

• Mentally or legally incapacitated or has significant emotional problems
• History or presence of clinically significant medical or psychiatric condition or disease in the opinion of the PI or designee.
• History or presence of alcohol or drug abuse within the past 2 years prior to the first dosing.
• History or presence of clinically significant GI disorder (
• Female subjects of childbearing potential.
• Positive urine drug screen or alcohol breath test results
• Positive results for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), or hepatitis C virus (HCV)
• Lactose intolerant.