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Completed

NCT Number: NCT02594345

Effect of Exosomes Derived From Red Blood Cell Units on Platelet Function and Blood Coagulation

This study is designed to analyze the effect exosomes derived from red blood cell units have on blood coagulation and platelet function. It is an in vitro study using healthy volunteers' blood.

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Key information

Conditions

Blood Coagulation Cardiovascular Diseases Embolism and Thrombosis Platelet Function Thrombosis Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital Frankfurt

Frankfurt am Main, Hesse, 60590, Germany

About this study

The blood of 25 healthy volunteers will be exposed to exosomes derived from red blood cell units. The effects on coagulation and platelet function will be measured using thromboelastometry (ROTEM®) and FACS analysis.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy volunteers

Exclusion criteria

  • pregnancy
  • drug use

Treatment and study plan

in vitro study

Other

Exosomes will be mixed with healthy volunteers' blood in vitro

Primary outcomes

  1. clotting time

    Time frame: 2 months

    measured by thromboelastometry (ROTEM® Analysis)

Secondary outcomes

  1. clot formation

    Time frame: 1h after exposure

    measured by thromboelastometry (ROTEM® Analysis)

  2. clot stability

    Time frame: 1h after exposure

    measured by thromboelastometry (ROTEM® Analysis)

  3. clot lysis

    Time frame: 1h after exposure

    measured by thromboelastometry (ROTEM® Analysis)

  4. CD62P

    Time frame: 3h after exposure

    FACS analysis

Sponsors and collaborators

Lead sponsor

Johann Wolfgang Goethe University Hospital

Other

Registry information

Official study title

In Vitro Study of the Effect of Exosomes Derived From Red Blood Cell Units on Platelet Function and Blood Coagulation in Healthy Volunteers' Blood

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
Nov 3, 2015
Registry last updated
Feb 23, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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