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OpenTrials
Completed

NCT Number: NCT04604717

Effect of Exercise Training on Salivary Immunoglobulin A in Patients With Chronic Obstructive Pulmonary Disease

The purpose of this study is to determine whether whole body exercise training alters the immunity in the lungs of people with COPD and reduces the incidence of chest infections over the longer term.

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Key information

Conditions

COPD Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

40 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Alfred Health, Melbourne, Victoria, Australia

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About this study

Patients will undertake an 8 weeks pulmonary rehabilitation program of exercise and education. Those who decline to take part in pulmonary rehabilitation will have the same outcome measures collected at the same timepoints.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of COPD (FEV1/FVC < 70), smoking Hx of minimum of 10 pack years

Exclusion criteria

  • Diagnosis of asthma, bronchiectasis, attendance at pulmonary rehabilitation within last 12 months, exacerbation of COPD within last 4 weeks

Treatment and study plan

Pulmonary Rehabilitation

Other

8 weeks of exercise training (twice weekly) of education and exercise

Primary outcomes

  1. Change in Salivary Immunoglobulin A levels

    Time frame: Change over 8 weeks

    SIgA

Secondary outcomes

  1. Change in circulatory inflammatory markers

    Time frame: Change over 8 weeks

  2. Change in physical activity levels

    Time frame: Change over 8 weeks

  3. Health status

    Time frame: Change over 8 weeks

    COPD assessment test

  4. Exercise capacity (6MWT)

    Time frame: Change over 8 weeks

    Distance walked in 6 minutes

  5. Number of acute exacerbations

    Time frame: 12 months

Sponsors and collaborators

Lead sponsor

Bayside Health

Other Gov

Collaborators

  • Austin Health
  • Newcastle University

Registry information

Important dates

Study start
2014
Primary completion
2017
Study completion
2017
First posted
Oct 27, 2020
Registry last updated
Oct 27, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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