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Completed

NCT Number: NCT01136083

Effect of Exercise Training on Angiogenesis and Cachexia in Lung Cancer Patients

Cancer is one of the leading health issues in this country and worldwide. Angiogenesis is an essential process for tumoral growth and metastasis. This process is dependent on the balance between angiogenic factors and antiangiogenic factors. Muscle wasting has been associated with myostatin overexpression in cancer. Exercise training can depress tumor growth and suppress myostatin expression, and enhance skeletal muscle angiogenesis in healthy people and some animal studies. The purpose of this study is mainly to investigate the effects of exercise training on

1. circulating VEGF-A 2. muscle growth and function 3. Myostatin

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Key information

Conditions

Non-Small-Cell Lung Cancer Bronchial Neoplasms Carcinoma, Bronchogenic Carcinoma, Non-Small-Cell Lung Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

40 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

National Taiwan University Hospital

Taipei, 100, Taiwan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 40-75 years
  • Advanced NSCLC
  • Eastern Cooperative Oncology Group performance status of 0 or 1
  • Targeted therapy for at least 8 weeks
  • Stable condition

Exclusion criteria

  • Severe metastasis, cardiopulmonary or musculoskeletal conditions may affect participation in exercise
  • Do not understand the verbal or written instructions

Treatment and study plan

Exercise Training

Behavioral

Subjects in exercise group will undergo individualized high aerobic interval training on treadmill for 30 minutes under the supervision of an experienced physical therapist 3 times a week and home exercise twice a week with accelerometer.

Other names: High intensity interval aerobic training

Usual Care

Other

Subjects in control group will not undergo individualized high aerobic interval training on treadmill. They will receive usual care as normally does in hospital.

Other names: Non-exercise or patient education

Primary outcomes

  1. Exercise capacity

    Time frame: 8 weeks after the start of the intervention

    Maximal oxygen consumption with Vmax229 Vastus lateral muscle oxygenation with NIRS

Secondary outcomes

  1. Imaging of muscle

    Time frame: 8 weeks and 16 weeks after the start of the intervention

    Measured by MRS

  2. Analysis of venous blood sample

    Time frame: 8 weeks andd 16 weeks after the start of the intervention

    Analysis of circulating VEGF-A and myostatin

  3. Quality of life

    Time frame: baseline, 8 weeks, 16 weeks

    Measured by questionnaire

  4. Exercise capacity

    Time frame: 16 weeks after the start of the intervention

    Maximal oxygen consumption with Vmax229 Vastus lateral muscle oxygenation with NIRS

  5. Muscle function

    Time frame: 8 weeks and 16 weeks after the start of the intervention

    Isokinetic muscle strength and endurance with Biodex

  6. Physical activity

    Time frame: 8 weeks andd 16 weeks after the start of the intervention

    Measured with 7-day recall questionnaire

  7. Dietary intake

    Time frame: 8 weeks andd 16 weeks after the start of the intervention

    Measured with 24-hour recall questionnaire

  8. Body composition

    Time frame: 8 weeks andd 16 weeks after the start of the intervention

    Body mass index calculated with body weight and height

    % body fat abd free-fat mass with BIA

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Collaborators

  • National Science and Technology Council, Taiwan

Registry information

Important dates

Study start
2010
Primary completion
2011
Study completion
2012
First posted
Jun 3, 2010
Registry last updated
Aug 13, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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