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OpenTrials
Completed

NCT Number: NCT03270475

Effect of Exercise on Muscle Proteome Signature

The aim of the study is to investigate skeletal muscle proteome signature changes induced by exercise training in young men

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Key information

Conditions

Healthy

Age range

18 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Department of Nutrition, Exercise and Sports

Copenhagen, 2100, Denmark

About this study

Advances in omics technologies have allowed for the identification of biomarkers with importance for the beneficial adaptations imposed by exercise training. Skeletal muscle exhibits remarkable plasticity to exercise training, as illustrated by pronounced alterations to the proteomic landscape, such as mitochondrial biogenesis. However, despite recent advances that have helped describe the proteomic landscape in response to a period of exercise training, our understanding of the processes pertaining to post-translation modification is scant. In this study, we aim to investigate the human acetylome and proteome in response to exercise training.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy
  • VO2max of 45-55 ml/kg/min (+/- SD) / 3000-4000 ml/min (+/- SD)
  • Body mass index (BMI) of 19-26 kg/m2
  • Normal ECG (electrocardiography)

Exclusion criteria

  • Serious adverse effects to exercise
  • Chronic disease

Treatment and study plan

Exercise training

Other

subjects complete 4-5 weeks of training

Primary outcomes

  1. Skeletal muscle proteome signature

    Time frame: Change from baseline proteome signature at 5 weeks

    proteomics

Other outcomes

  1. Skeletal muscle acetylome signature

    Time frame: Change from baseline acetylome signature at 5 weeks

    acetylomics

  2. Skeletal muscle mitochondrial respiration

    Time frame: Change from baseline at 5 weeks

    Mitochondrial respiratory capacity

  3. Maximal oxygen uptake

    Time frame: Change from baseline at 5 weeks

    Maximal oxygen uptake

Sponsors and collaborators

Lead sponsor

Morten Hostrup, PhD

Other

Registry information

Official study title

Effect of Exercise Training on Skeletal Muscle Proteome Signature of Young Men

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
Sep 1, 2017
Registry last updated
Jan 15, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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