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Completed

NCT Number: NCT00804518

Effect of Exercise on Heart Function in Healthy Elderly People

The purpose of this study is to determine the effect of aerobic interval training on left- and right ventricular diastolic- and systolic function on healthy, sedate people over 70 years. The old sedate cohort will be compared to young, sedate subjects also performing aerobic interval training and old master athletes without intervention.

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Key information

Conditions

Diastolic Dysfunction Behavior Motor Activity

Age range

70 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ntnu/Dmf/Isb

Trondheim, Sør-Trøndelag, 7489, Norway

About this study

Aging is associated with a reduced diastolic and systolic function of the heart. Earlier studies have shown that physical exercise can improve both systolic and diastolic function. However the impact on age-related cardiac function is to some extent conflicting. The use of different training intensities will impact on the cardiac result. We have in earlier studies shown aerobic interval training at 90 % of maximal heart rate (4x4 minutes) to have more impact on cardiac function, endothelial function and maximal oxygen uptake compared to moderate intensity.

To our knowledge the effect of aerobic interval training on cardiac function has not been studied in an old, sedate group before.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • over 70 years, healthy
  • not exercising more than twice per week

Exclusion criteria

  • chronic illness
  • chronic use of any medication
  • regular smoking
  • metabolic or cardiovascular diseases

Treatment and study plan

Aerobic interval training

Other

High intensity aerobic interval training consists of 10 minutes warm up at ~60% of maximal heart rate, 4x4 minutes intervals at 90-95 % of maximal heart rate corresponding to 85-90% of VO2max) walking/running uphill on a treadmill, with three minutes active pause between the exercise bouts at 60-70% maximal heart rate. The session is terminated with 3 minutes cool down. Total exercise time is 38 minutes.The training is supervised by an exercise physiologist and the subjects train 3 times per week for 12 weeks.

Primary outcomes

  1. Improvement of left and right ventricular early diastolic tissue velocity at rest and sub maximal exercise ,e'.

    Time frame: 12 weeks

Secondary outcomes

  1. Improvement of left and right ventricular systolic tissue velocity function at rest and sub maximal exercise, S'.

    Time frame: 12weeks

Sponsors and collaborators

Lead sponsor

Norwegian University of Science and Technology

Other

Registry information

Official study title

Aerobic Interval Training Reduces and Compensates Age Related Decline in Cardiac Function

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Dec 9, 2008
Registry last updated
Jul 18, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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