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OpenTrials
Completed

NCT Number: NCT01080625

Effect of Epinephrine/ Phenylephrine for Preventing the Postreperfusion Syndrome During Reperfusion in Liver Transplantation

Postreperfusion syndrome (PRS) is a relatively common phenomenon in patients undergoing liver transplantation which is characterized by an acute drop in blood pressure immediately after the prefusion is restored to the transplanted liver. We hypothesized that PRS would be prevented when phenylephrine or epinephrine is administered immediately prior to reperfusion in liver transplantation.

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Key information

Conditions

Hypotension After Reperfusion in Liver Transplantation

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul National University Hospital

Seoul, 110-744, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adults scheduled to undergo liver transplantation

Exclusion criteria

  • pediatric liver transplantation

Treatment and study plan

Phenylephrine

Drug

100 mcg of phenylephrine (volume 10 ml) iv at the time of reperfusion

Epinephrine

Drug

10mcg of epinephrine (volume 10 ml) is administered iv at the time of reperfusion

Placebo Control

Drug

10ml of normal saline is administered at the time of reperfusion

Primary outcomes

  1. Occurrence of Postreperfusion Syndrome (PRS)

    Time frame: immediately after reperfusion

    the number of patients who showed PRS (hypotension defined as < 30% of baseline mean arterial pressure [MAP] lasting over 1 min immediately after reperfusion of liver graft) was divided by the total number of patients enrolled for each group

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Official study title

Effect of Preventive Medicine on the Postreperfusion Syndrome

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
Mar 4, 2010
Registry last updated
May 3, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.