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NCT Number: NCT06619249

Effect of Endurance Training-Induced Coenzyme Q10 (CoQ10) Supplementation on Myokine, Exerkine Secretion and Cognitive Functions in Long-Distance Runners

The goal of this clinical trial is to learn if CoQ10 amplifies endurance training-induced myokine and exerkine secretion and if those changes influences cognition in long-distance runners.

Does 4-week high-dosage CoQ10 supplementation increase the secretion of myokine, exerkine sercetion? Does the above-mentioned intervention improve the cognitive function in long distance runners?

Participants will:

Take CoQ10 or a placebo every day for 4 weeks. Visit the laboratory once every 4 weeks for checkups and tests. Keep the participants' food and training diary.

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Key information

Conditions

Health Knowledge, Attitudes, Practice Behavior

Age range

30 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 4

Primary location

Gdansk University of Physical Education and Sport

Gdansk, 80-333, Poland

Location status: Recruiting

Location contact

Zbigniew Jost, PhD

CONTACT

[email protected]

+48663892068

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • training experienced for minimum 2 years
  • running training at least 2 times per week
  • Personal Best on 10k (<50 minutes)

Exclusion criteria

  • taking supplements which can interrupt primary outcomes (vitamin D, omega-3 fatty acids)
  • injured in last 6 months to avoid n number reduction

Treatment and study plan

CoQ10 supplementation

Dietary Supplement

Long-distance runners will be supplemented with CoQ10 for 4 weeks in cross-over manner with 4 weeks of wash out period.

Placebo supplementation

Dietary Supplement

Long-distance runners will be supplemented with placebo for 4 weeks in cross-over manner with 4 weeks of wash out period.

Primary outcomes

  1. Change in cognitive funtions as a result of CoQ10 supplementation measured via cogntitive function test.

    Time frame: The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10

    The investigators assume that supplementation with CoQ10 will change cognition (measured via cognitive function tests - Stroop Test, Trial Making Test A and Trial Making Test B) in long-distance runners. The results will be obtained as time (seconds) needed to complete tasks while testing.

  2. Change in myokine and exerkine concentration in the blood plasma as a result of CoQ10 supplementation.

    Time frame: The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10

    The investigators will assess the concentration of blood myokine and exerkine concentration (pg or ug/dl) of blood plasma using the colorimetric method.

Secondary outcomes

  1. Change in aerobic capacity measured via direct test to volitional exhaustion on a motorized treadmill

    Time frame: The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10

    The investigators assume that supplementation with CoQ10 will change the aerobic capacity (oxygen uptake in ml-1 x min-1 x kg-1) in long-distance runners. The determination of aerobic capacity will be done through progressive test to volitional exhaustion on a motorized treadmill and gas analyzer

Sponsors and collaborators

Lead sponsor

Gdansk University of Physical Education and Sport

Other

Registry information

Important dates

Study start
2024
Primary completion
2025
Study completion
2026
First posted
Oct 1, 2024
Registry last updated
Aug 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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