Effect of Enalapril Plus Folic Acid on Blood Pressure and Glycometabolism

Inclusion criteria

• Age≥18 years and less than 75 years
• Essential hypertension patients
• Sedentary systolic blood pressure≥140mmHg and less than 180mmHg, and/or sedentary diastolic blood pressure≥90mmHg and less than 110mmHg
• Reproductive women agree to take a reliable contraception measure during the trial
• Written informed consent

Exclusion criteria

• Pregnant women
• Women within lactateion period
• Hypersensitive to Angiotensin-Converting Enzyme Inhibitor (ACEI) or folic acid
• Easily hypersensitiveness
• Diagnosed secondum hypertension or skeptical secondum hypertension
• Severe hypertension (sedentary systolic blood pressure greater than or equal to 180 mmHg and/or sedentary diastoleic blood pressure greater than or equal to 110 mmHg)
• Severe diseases:

• Cardiovascular system
• Diagnosed cardia insufficiency (New York Health Association [NYHA] III level and higher)
• Hypertrophic obstructive cardiomyopathy (HOCM)
• Clinical significantly Valvular Disease of the Heart (VDH)
• Acute coronary syndrome or coronary artery interventional therapy or coronary artery bypass graft within three months
• Severe arrhythmia such as atrial flutter, atrial fibrillation, ventricular arrhythmia above Lown ?, atrioventricular block above II level, etc.
• Alimentary system disorders
• Active virus hepatitis
• Any of alanine aminotransferase (ALT), aspartate aminotransferase (AST), galactosylhydroxylysyl glucosyltransferase (GGT), alkaline phosphatase (ALP), total bilirubin (TBIL), Direct Bilirubin (DB) was above 2 times of it's normal value upper limit, albumin (ALB) greater than 30 g/L
• Stomach bulk resect and gastrojejunostomy, stomach intestine malabsorption

Urinary system:

• Serum creatinine greater than or equal to 200 mmol/L
• Diagnosed stenosis of renal artery, solitary kidney
• Renal transplantation

Endocrine system:

• Type 1 diabetes mellitus or uncontrolled type 2 diabetes mellitus (fasting glucose greater than or equal to 11.1 mmol/L)
• Diagnosed and uncontrolled hyperthyrosis

Respiratory system:

• Chronic cough nervous or psyche system:
• Transient Ischemia Attach (TIA) or stoke within 3 months
• Severe peripheral nerve or vegetative nerve functional disturbance
• Psyche or nervous system dysfunction
• Drugs or alcohol dependence

Others:

• Malignant tumor
• Malnutrition, haematogenesis dysfunction, etc.
• Taking other antihypertensive drugs
• Taking folic acid or other Vitamin B groups

Primary Outcome Measures:

• Blood pressure of study participants was measured at baseline, 2th week, 4th week, 6th week and at the end of trial
• Subjects' plasma total homocysteine concentration were measured at baseline, 4th week and at 8th week.

Secondary Outcome Measures:

• Participants' living habit and life style were collected at baseline with the original questionnaires.
• A follow up questionnaire was sent out at 2th week, 4th week, 6th week and at the end of the trial.

Inclusion criteria

• Age≥18 years and less than 75 years
• Essential hypertension patients
• Sedentary systolic blood pressure≥140mmHg and less than 180mmHg, and/or sedentary diastolic blood pressure≥90mmHg and less than 110mmHg
• Reproductive women agree to take a reliable contraception measure during the trial
• Written informed consent

Exclusion criteria

• Pregnant women
• Women within lactateion period
• Hypersensitive to angiotensin-converting enzyme inhibitor (ACEI) or folic acid
• Easily hypersensitiveness
• Diagnosed secondum hypertension or skeptical secondum hypertension
• Severe hypertension (sedentary systolic blood pressure≥180mmHg and/or sedentary diastoleic blood pressure≥110mmHg)

Severe diseases:

• Cardiovascular system:

• Diagnosed cardia insufficiency (NYHAⅢ level and higher)
• Hypertrophic obstructive cardiomyopathy (HOCM)
• Clinical significantly valvular disease of the heart (VDH)
• Acute coronary syndrome or coronary artery interventional therapy or coronary artery bypass graft within three months
• Severe arrhythmia such as atrial flutter, atrial fibrillation, ventricular arrhythmia above Lown Ⅱ, atrioventricular block above Ⅱ level, et al
• Alimentary system:

• Active virus hepatitis
• Any of alanine aminotransferase (ALT), aspartate aminotransferase (AST), galactosylhydroxylysyl glucosyltransferase (GGT), alkaline phosphatase (ALP), total bilirubin (TBIL), direct bilirubin (DB) was above 2 times of it's normal value upper limit, albumin (ALB)>30g/L
• Stomach bulk resect and gastrojejunostomy, stomach intestine malabsorption
• Urinary system:

• Serum creatinine≥200mmol/L
• Diagnosed stenosis of renal artery, solitary kidney
• Renal transplantation
• Endocrine system:

• Type 1 diabetes mellitus or uncontrolled type 2 diabetes mellitus (fasting glucose≥11.1mmol/L)
• Diagnosed and uncontrolled hyperthyrosis
• Respiratory system:

• Chronic cough
• Nervous or psyche system
• Transient ischemia attach (TIA) or stoke within 3 months
• Severe peripheral nerve or vegetative nerve functional disturbance
• Psyche or nervous system dysfunction
• Drugs or alcohol dependence
• Others:

• Malignant tumor, malnutrition, haematogenesis dysfunction, et al
• Taking other antihypertensive drugs
• Taking folic acid or other Vitamin B groups