Effect of Empagliflozin on Peritoneal and Kidney Function in End Stage Renal Disease

Participants will undergo three study visits, and up to 4 safety visits, over 9 weeks.

At 7 AM in the first study visit, the participants will have taken 25mg empagliflozin once or matching placebo, thus producing peak plasma levels by 10 AM. One week later the participant will return for the crossed over to the alternate study drug.

At the conclusion of the 2nd study visit, all participants will be provided with empagliflozin 10mg tabs to be taken daily for 56 days (8 weeks). At each study visit and safety visit, participants will undergo a PET test.

Inclusion criteria

• Patients actively undergoing PD with a reliably functioning PD catheter
• Stable peritoneal dialysis prescription
• PD vintage > 3 months
• Age >18 years of age

Exclusion criteria

• History of type 1 diabetes, diabetic ketoacidosis, "brittle" diabetes or frequent hypoglycemia or severe hypoglycemic episodes requiring emergent intervention (ER visit or EMS response, glucagon administration or forced oral carbs) in the last 6 months
• Use of an SGLT2 inhibitor within the prior 30 days
• 1 or more episodes of peritonitis in the previous 6 months or active infection of the peritoneal dialysis catheter
• Anemia with hemoglobin <8g/dL
• Inability to give written informed consent or follow study protocol
• Contraindication to receiving loop diuretics