Skip to main content
OpenTrials
Completed

NCT Number: NCT06287554

Effect of Early Implementation of Prone Positioning

Background and objective: The ramifications of early lung protective measures and prone positioning on the ICU length of stay rates of participants admitted to the ICU with acute respiratory distress syndrome amid the COVID-19 pandemic constitute a pivotal examination. The study aims to identify the effect of early prone positioning on the length of stay, discharge rate, and number of tracheostomized patients in the ICU.

Completed

Looking for future studies?

Notify Me

Key information

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Al-Azhar faculty of medicine

Cairo, 12546, Egypt

About this study

Background and objective: The ramifications of early lung protective measures and prone positioning on the ICU length of stay rates of participants admitted to the ICU with acute respiratory distress syndrome amid the COVID-19 pandemic constitute a pivotal examination. The study aims to identify the effect of early prone positioning on the length of stay, discharge rate, and number of tracheostomized patients in the ICU.

Methodology: This retrospective study was conducted on critically ill patients needing mechanical ventilation with lung protective strategy and admitted to the Intensive Care Units of Al-Azhar University Hospitals between March 2020 to April 2022. All patients in the study were interpreted retrospectively by examining the patient's records. Group A (n:39) included patients who had been early placed in prone positions within 24 hours of intubation, and Group B (n:31) included patients who had not been placed in prone positions. All patients received a lung protective strategy for ARDS. In both groups, PaO2, PaCo2, PH, SpO2, and PaO2/FiO2 ratio were checked initially and later every 24 hours for 6 days. All patients were evaluated for the total days of both hospital and ICU length of stay, number of successful discharges to home from the hospital, and the total number of tracheostomized patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients of both sexes.
  • Aged from 18 to 70 years.
  • Body Mass Index (BMI) from 25 to 35 kg/m2.
  • Critically ill due to ARDS resulting from COVID-19 pneumonia.

Exclusion criteria

  • Patients who spent more than 24 hours on mechanical ventilators before enrolment in the study.
  • Patients who died within the first 24 hours of presentation.
  • Patients with advanced cancer.
  • Pregnant patients.

Treatment and study plan

Prone position

Other

early placed in prone positions within 24 hours of intubation

Primary outcomes

  1. Number of discharged patients

    Time frame: 26 MONTHS

    Number of discharged patients

Secondary outcomes

  1. The total length of stay

    Time frame: 26 MONTHS

    The total length of stay

  2. ICU length of stay

    Time frame: 26 MONTHS

    ICU length of stay

  3. Patients who underwent tracheostomy procedures

    Time frame: 26 MONTHS

    Patients who underwent tracheostomy procedures

Sponsors and collaborators

Lead sponsor

Zulekha Hospitals

Other

Collaborators

  • Al-Azhar University

Registry information

Official study title

Effect of Early Implementation of Prone Positioning Among Critically Ill Patients Admitted With Acute Respiratory Distress Syndrome During the COVID-19 Time: A Comparative Retrospective Observational Study

Acronym: prone

Important dates

Study start
2020
Primary completion
2022
Study completion
2022
First posted
Mar 1, 2024
Registry last updated
Mar 1, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.