Effect of Early Enteral Nutrition on Serum Acetylcholine Level and Inflammation in Critically Ill Patients

Early enteral nutrition(EEN) is an important treatment for critical ill patients and attenuate systemic inflammation, but the mechanisms are not clear. Thus the investigator conducted this study to observe if EEN affects systemic inflammation though regulation of blood acetylcholine

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Key information

Conditions

Critical Illness Disease Attributes Enteral Nutrition Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

initiating enteral nutrition within the first 24-48h after intensive care unit (ICU) admission
age more than 18 years
Acute Physiology and Chronic Health Evaluation II (APACHE II) score >8

Exclusion criteria

not expected to survive 24 hours
pregnancy
any terminal stage disease

Treatment and study plan

Primary outcomes

28-day mortality

Time frame: 14 months

The number of survival and non-survival patients 28 days after inclusion
Intestinal barrier function within one week

Time frame: 14 months

The measurement of serum d-lactate was applied to evaluate the intestinal barrier function

Sponsors and collaborators

Lead sponsor

Nanjing PLA General Hospital

Other

Registry information

Important dates

Study start: 2017
Primary completion: 2018
Study completion: 2018
First posted: Aug 2, 2018
Registry last updated: Aug 2, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed