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NCT Number: NCT06949696

Effect of Dual-Task Training and Cognitive Rehabilitation in Individuals With Multiple Sclerosis.

The purpose of this study is to examine the effects of dual-task training and cognitive rehabilitation on gait, balance, fatigue and cognitive performance in individuals with multiple sclerosis.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mersin University

Mersin, 33140, Turkey (Türkiye)

Location status: Recruiting

Location contact

Aysun Katmerlikaya, MSc

CONTACT

Öznur Tunca, Prof. Dr.

CONTACT

About this study

Multiple sclerosis (MS) is a complex disease characterized by chronic, inflammatory, demyelinating and neurodegenerative processes of the central nervous system (CNS) with heterogeneous clinical symptoms. Balance, gait and cognitive impairment are among the biggest problems in individuals with MS and significantly affect their daily lives.

Dual Task (DT); is the process of performing two tasks that can be performed independently and have different purposes simultaneously. Walking with dual tasks has recently been shown to resemble typical walking performance in daily life, thus providing clinicians with a realistic walking performance measurement in daily life. Although the effects of dual task performance in various neurological diseases have been partially described in the literature, the comparison of dual task training and cognitive rehabilitation on walking, balance, fatigue and cognitive performance has not been made and due to this deficiency in the literature, our study was planned and has originality. The aim of our study is to investigate the effects of dual task training and cognitive rehabilitation on walking, balance, fatigue and cognitive performance in individuals with MS.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Definite MS diagnosis by a neurologist
  • Can walk independently
  • Expanded Disability Status Scale (EDSS) score below 5
  • Has not had an attack in the last 3 months, has been medically stable for 6 months
  • Has not received a regular physiotherapy program in the last 6 months volunteer

Exclusion criteria

  • Scoring 26 or below on the Montreal Cognitive Assessment Scale (MoCA)
  • Having systemic, orthopedic and neurological problems that may affect walking and balance in the assessments
  • Having additional psychiatric disorders

Treatment and study plan

Dual task training

Other

In dual task training, patients will be given cognitive exercises such as counting backwards from 100 by 3, counting the names of cities, girls and boys while walking.

cognitive rehabilitation

Other

In cognitive rehabilitation, patients will be given paper-and-pencil activities and exercises to find the difference between two pictures.

Conventionel Physiotherapy

Other

In conventionel physiotherapy, patients will be given posture exercises for balance and strengthening.

Primary outcomes

  1. Dynamic Gait Index (DGI)

    Time frame: a year

    DGI is a test that measures the capacity to adapt to changes in walking.It evaluates a total of 8 parameters over 24 points. Values of 19 points and below define the presence of a fall risk.

Secondary outcomes

  1. Timed 25 Food Walk Test (T25FWT)

    Time frame: a year

    Timed 25 Food Walk Test is a test that evaluates walking speed. In the test, the patient is asked to walk 25 steps as quickly and safely as possible and the time is recorded in seconds with the average of 2 trials.

  2. The 12-item MS Walking Scale (12-MSWS)

    Time frame: a year

    The 12-item MS Walking Scale (12-MSWS) that evaluates walking ability over the last 2 weeks, scaled from 0 to 100.

  3. BICAMS (Brief International Cognitive Assessment for MS)

    Time frame: a year

    BICAMS (Brief International Cognitive Assessment for MS) is an international initiative to recommend and support a cognitive assessment that is brief, practical and universal.

  4. Trial Making Test (TMT)

    Time frame: a year

    Trial Making Test (TMT)is used to evaluate individuals' executive functions, visual-motor perception, visual scanning and attention speed, motor function, organization, and planning.

  5. Modified Fatigue Impact Scale (MFIS)

    Time frame: a year

    It is a multidimensional self-report questionnaire consisting of 21 questions in total, which is frequently used in individuals with MS and evaluates subjective fatigue physically (9 items), cognitively (10 items) and psychosocially (2 items).

Study contacts

Contact information is provided by the study sponsor or research team.

Aysun Katmerlikaya, MSc

CONTACT

[email protected]

Öznur Tunca, MSc

CONTACT

03123051080

Sponsors and collaborators

Lead sponsor

Toros University

Other

Registry information

Official study title

Effects of Dual-Task Training and Cognitive Rehabilitation on Gait, Balance, Fatigue and Cognitive Performance in Individuals With Multiple Sclerosis

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Apr 29, 2025
Registry last updated
Apr 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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