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Completed

NCT Number: NCT05855785

Effect of Dual Task Exercise on Cognitive and Physical Function in the Elderly With Mild Cognitive Impairment

The purpose of this study is to investigate the effect of the dual task exercise program on cognitive and physical function in the elderly with mild cognitive impairment.

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Key information

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul National University Boramae Medical Center

Seoul, 07061, South Korea

About this study

All participants provided written informed consent before study participation. A total of 12 community-dwelling participants were randomized either to the exercise group or to the control group.

The exercise group underwent 8-week, 3 times a week, 60-minute group exercise sessions, which were comprised of moderate-to-high intensity exercise and simultaneous cognitive tasks. They also performed moderate-intensity home aerobic exercises for at least 60 minutes per week. The control group performed 60-minute light intensity home exercise, 4 times a week for 8 weeks.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • a score on the Korean Montreal Cognitive Assessment (MoCA-K) of 25 points or below
  • aged 65 or more
  • no physical or medical problem which impairs moderate to vigorous physical activity

Exclusion criteria

  • uncontrolled or unstable cardiovascular disease
  • malignancy affecting general condition
  • musculoskeletal problems affecting motor performance
  • speech and hearing impairment
  • other organic brain diseases

Treatment and study plan

Dual task exercise

Behavioral

8-week, 3 times a week, 60-minute group exercise sessions, which were comprised of moderate-to-high intensity exercise and simultaneous cognitive tasks

Home exercise

Behavioral

60-minute light intensity home exercise, 4 times a week for 8 weeks

Primary outcomes

  1. Dual task cost in Timed up and go (TUG)

    Time frame: Baseline

    Participants completed both single-task (ST) and dual-task (DT) tests at baseline and post-intervention.

    For a ST condition, participants performed motor task only such as Timed up and go (TUG). TUG measured the time of taking to rise from a chair, walking three meters, turning around 180 degrees, walking back to the chair, and sitting down while turning 180 degrees. For a DT condition, participants performed TUG while performing serial 3 simultaneously. Serial 3 is descending subtraction task, where the patient counts down from one hundred by threes. In the DT condition, participants were given no instruction regarding the prioritization of one task over the other. We calculated TUG duration in both conditions. Dual task cost(DTC) were calculated as a percentage as follows: (%DTC) = [dual task duration or speed - single task duration or speed] / [single task duration or speed] * 100%. The lower DTC indicates efficiency in cognitive-motor interplay and good dual task ability.

  2. Dual task cost in 10-meter walking test

    Time frame: Baseline

    Participants completed both single-task (ST) and dual-task (DT) tests at baseline and post-intervention.

    For a ST condition, participants performed motor task only such as 10-meter walking test (10MWT). 10MWT is a performance measure used to assess walking speed over a short distance. For a DT condition, participants performed 10MWT while performing serial 3 simultaneously. Serial 3 is descending subtraction task, where the patient counts down from one hundred by threes. In the DT condition, participants were given no instruction regarding the prioritization of one task over the other. We calculated 10MWT gait speed in both conditions. Dual task cost(DTC) were calculated as a percentage as follows: (%DTC) = [dual task duration or speed - single task duration or speed] / [single task duration or speed] * 100%. The lower DTC indicates efficiency in cognitive-motor interplay and good dual task ability.

  3. Dual task cost in Timed up and go (TUG)

    Time frame: immediately after the 8-week intervention

    Participants completed both single-task (ST) and dual-task (DT) tests at baseline and post-intervention.

    For a ST condition, participants performed motor task only such as Timed up and go (TUG). TUG measured the time of taking to rise from a chair, walking three meters, turning around 180 degrees, walking back to the chair, and sitting down while turning 180 degrees. For a DT condition, participants performed TUG while performing serial 3 simultaneously. Serial 3 is descending subtraction task, where the patient counts down from one hundred by threes. In the DT condition, participants were given no instruction regarding the prioritization of one task over the other. We calculated TUG duration in both conditions. Dual task cost(DTC) were calculated as a percentage as follows: (%DTC) = [dual task duration or speed - single task duration or speed] / [single task duration or speed] * 100%. The lower DTC indicates efficiency in cognitive-motor interplay and good dual task ability.

  4. Dual task cost in 10-meter walking test

    Time frame: immediately after the 8-week intervention

    Participants completed both single-task (ST) and dual-task (DT) tests at baseline and post-intervention.

    For a ST condition, participants performed motor task only such as 10-meter walking test (10MWT). 10MWT is a performance measure used to assess walking speed over a short distance. For a DT condition, participants performed 10MWT while performing serial 3 simultaneously. Serial 3 is descending subtraction task, where the patient counts down from one hundred by threes. In the DT condition, participants were given no instruction regarding the prioritization of one task over the other. We calculated 10MWT gait speed in both conditions. Dual task cost(DTC) were calculated as a percentage as follows: (%DTC) = [dual task duration or speed - single task duration or speed] / [single task duration or speed] * 100%. The lower DTC indicates efficiency in cognitive-motor interplay and good dual task ability.

Secondary outcomes

  1. Korean Montreal Cognitive Assessment (MoCA-K)

    Time frame: Baseline

    MoCA-K is a screening test to assess cognitive functions such as attention, concentration, execution, memory, vocabulary, visual space, abstraction, and calculation. MoCA-K is a test for mild cognitive impairment and it takes about 10 minutes to run. It assesses cognitive functions such as attention, concentration, execution, memory, vocabulary, visual space, abstraction, calculation and support. Of a maximum 30 points, a score of 25 or higher is considered normal.

  2. Korean Montreal Cognitive Assessment (MoCA-K)

    Time frame: immediately after the 8-week intervention

    MoCA-K is a screening test to assess cognitive functions such as attention, concentration, execution, memory, vocabulary, visual space, abstraction, and calculation. MoCA-K is a test for mild cognitive impairment and it takes about 10 minutes to run. It assesses cognitive functions such as attention, concentration, execution, memory, vocabulary, visual space, abstraction, calculation and support. Of a maximum 30 points, a score of 25 or higher is considered normal.

  3. Korean Mini Mental Status Examination (K-MMSE)

    Time frame: Baseline

    K-MMSE is a screening test for dementia that can evaluate various areas of cognitive function in a short time of 5 to 10 minutes such as time orientation, place orientation, memory, attention and calculation, understanding and judgment, and language. Of a maximum 30 points, a score of less than 24 is considered dementia.

  4. Korean Mini Mental Status Examination (K-MMSE)

    Time frame: immediately after the 8-week intervention

    K-MMSE is a screening test for dementia that can evaluate various areas of cognitive function in a short time of 5 to 10 minutes such as time orientation, place orientation, memory, attention and calculation, understanding and judgment, and language. Of a maximum 30 points, a score of less than 24 is considered dementia.

  5. Computerized cognitive test(digit span test, visual learning test, verbal learning test, the Stroop Color and Word test, Boston naming test, trail making test, and verbal fluency test)

    Time frame: Baseline

    Computerized cognitive test is a test method which quantitatively measures patients' cognitive problems in a systematic and standardized manner using a computer. Various neurocognitive function tests such as attention, memory, memory-motor coordination, and comprehensive cognitive thinking ability are possible through computerized cognitive test. Card sorting test, digit span test, visual learning test, verbal learning test, and Stroop word color test were conducted for precise cognitive function evaluation.

  6. Computerized cognitive test(digit span test, visual learning test, verbal learning test, the Stroop Color and Word test, Boston naming test, trail making test, and verbal fluency test)

    Time frame: immediately after the 8-week intervention

    Computerized cognitive test is a test method which quantitatively measures patients' cognitive problems in a systematic and standardized manner using a computer. Various neurocognitive function tests such as attention, memory, memory-motor coordination, and comprehensive cognitive thinking ability are possible through computerized cognitive test. Card sorting test, digit span test, visual learning test, verbal learning test, and Stroop word color test were conducted for precise cognitive function evaluation.

  7. Short Physical Performance Battery (SPPB)

    Time frame: Baseline

    SPPB is a group of measures that combines the results of the gait speed, chair stand and balance tests. It has been used as a predictive tool for possible disability and can aid in the monitoring of function in older people . The scores range from 0 (worst performance) to 12 (best performance).

  8. Short Physical Performance Battery (SPPB)

    Time frame: immediately after the 8-week intervention

    SPPB is a group of measures that combines the results of the gait speed, chair stand and balance tests. It has been used as a predictive tool for possible disability and can aid in the monitoring of function in older people . The scores range from 0 (worst performance) to 12 (best performance).

  9. Berg Balance Scale (BBS)

    Time frame: Baseline

    BBS is an evaluation tool designed to measure the balance of the elderly and consists of 56 points in 14 items that apply daily life movements. It is a measure to objectively evaluate static and dynamic balance ability in various postures such as sitting, standing, and posture change. Higher score means well balance function.

  10. Berg Balance Scale (BBS)

    Time frame: immediately after the 8-week intervention

    BBS is an evaluation tool designed to measure the balance of the elderly and consists of 56 points in 14 items that apply daily life movements. It is a measure to objectively evaluate static and dynamic balance ability in various postures such as sitting, standing, and posture change. Higher score means well balance function.

  11. Falls Efficacy Scale (FES)

    Time frame: Baseline

    FES is a questionnaire that evaluates the confidence to perform the activities without falling from the 10 activities. Higher score means good function.

  12. Falls Efficacy Scale (FES)

    Time frame: immediately after the 8-week intervention

    FES is a questionnaire that evaluates the confidence to perform the activities without falling from the 10 activities. Higher score means good function.

  13. Activities-specific Balance Confidence (ABC)

    Time frame: Baseline

    ABC consists of 16 surveys and it evaluates level of self-confidence in doing the activity without losing balance or becoming unsteady by choosing one of the percentage points on the scale from 0% to 100%.

  14. Activities-specific Balance Confidence (ABC)

    Time frame: immediately after the 8-week intervention

    ABC consists of 16 surveys and it evaluates level of self-confidence in doing the activity without losing balance or becoming unsteady by choosing one of the percentage points on the scale from 0% to 100%.

  15. Grip strength

    Time frame: Baseline

    Grip strength was measured by hand dynamometer for evaluating muscle strength. It is measured using pound(lb).

  16. Grip strength

    Time frame: immediately after the 8-week intervention

    Grip strength was measured by hand dynamometer for evaluating muscle strength. It is measured using pound(lb).

  17. Korean version of Physical Activity Scale for the Elderly (K-PASE)

    Time frame: Baseline

    K-PASE measures various physical activities of the elderly which are divided into sedentary life, leisure time activities, housework activities, and work-related activities. The score is calculated by multiplying the level and frequency of each activity using the conversion table. Higher score means higher activity.

  18. Korean version of Physical Activity Scale for the Elderly (K-PASE)

    Time frame: during intervention(8 weeks)

    K-PASE measures various physical activities of the elderly which are divided into sedentary life, leisure time activities, housework activities, and work-related activities. The score is calculated by multiplying the level and frequency of each activity using the conversion table. Higher score means higher activity.

  19. International Physical Activity Questionnaires Short form (IPAQ)

    Time frame: Baseline

    IPAQ Short form consists of 7 surveys and evaluate the degree of physical activity and the time spent on physical activity for one week.

  20. International Physical Activity Questionnaires Short form (IPAQ)

    Time frame: during intervention (8 weeks)

    IPAQ Short form consists of 7 surveys and evaluate the degree of physical activity and the time spent on physical activity for one week.

  21. Metabolic Equivalent Task (MET) minutes per week

    Time frame: Baseline

    MET minutes per week were evaluated to measure the degree of physical activity before intervention and every week during 8 weeks of intervention. MET minutes per week was calculated based on IPAQ.

  22. Metabolic Equivalent Task (MET) minutes per week

    Time frame: during intervention(8 weeks)

    MET minutes per week were evaluated to measure the degree of physical activity before intervention and every week during 8 weeks of intervention. MET minutes per week was calculated based on IPAQ.

  23. Bioelectrical Impedance Analysis

    Time frame: Baseline

    Bioelectrical Impedance Analysis was evaluated using Inbody for changes in body composition before and after intervention. Specifically, body weight, body fat percent, body mass index (BMI), skeletal muscle mass, lean mass, fat mass, waist hip ratio were evaluated.

  24. Bioelectrical Impedance Analysis

    Time frame: immediately after the 8-week intervention

    Bioelectrical Impedance Analysis was evaluated using Inbody for changes in body composition before and after intervention. Specifically, body weight, body fat percent, body mass index (BMI), skeletal muscle mass, lean mass, fat mass, waist hip ratio were evaluated.

  25. Exercise Identity Scale (EIS)

    Time frame: Baseline

    Exercise Identity Scale (EIS) is a measure of how important exercise is in daily life

  26. Exercise Identity Scale (EIS)

    Time frame: immediately after the 8-week intervention

    Exercise Identity Scale (EIS) is a measure of how important exercise is in daily life

  27. Psychological Need Satisfaction in Exercise Scale (PNSE)

    Time frame: Baseline

    Psychological Need Satisfaction in Exercise Scale (PNSE) is an exercise psychological measure consisting of detailed items of self-confidence, autonomy, and belonging related to exercise.

  28. Psychological Need Satisfaction in Exercise Scale (PNSE)

    Time frame: immediately after the 8-week intervention

    Psychological Need Satisfaction in Exercise Scale (PNSE) is an exercise psychological measure consisting of detailed items of self-confidence, autonomy, and belonging related to exercise.

  29. Godin Leisure Time Exercise Questionnaire (GLTEQ)

    Time frame: Baseline

    Godin Leisure Time Exercise Questionnaire (GLTEQ) is a self-report measure of the frequency of light-intensity, moderate-intensity, and vigorous-intensity leisure-time physical activity. It evaluated how satisfied the participants were with the intervention.

  30. Godin Leisure Time Exercise Questionnaire (GLTEQ)

    Time frame: immediately after the 8-week intervention

    Godin Leisure Time Exercise Questionnaire (GLTEQ) is a self-report measure of the frequency of light-intensity, moderate-intensity, and vigorous-intensity leisure-time physical activity. It evaluated how satisfied the participants were with the intervention.

Sponsors and collaborators

Lead sponsor

Seoul National University Boramae Hospital

Other

Collaborators

  • National Rehabilitation Center, Ministry of Health and Welfare, Korea

Registry information

Official study title

Effect of Dual-task Exercise on Cognitive and Physical Function in the Elderly With Mild Cognitive Impairment: a Randomized Controlled Trial

Important dates

Study start
2020
Primary completion
2020
Study completion
2021
First posted
May 11, 2023
Registry last updated
May 11, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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