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Completed

NCT Number: NCT04482907

Effect of Dill in Thyroiditis and Nodular Goiter Patients

The aim of the study was to investigate the functional and morphological effects of Anethum graveolens L. in patients with thyroiditis and nodular goiter by evaluating hormone levels, anti-Inflammatory markers and comparing thyroid nodule sizes measured by ultrasonography for 90 days.

The effect of Anethum graveolens L. was evaluated in euthyroid goiter patients diagnosed with benign thyroid nodule via fine needle aspiration biopsy. Aerial parts of Anethum graveolens L. were dried and grinded to yield a fine powder. Size 1 hydroxypropyl methylcellulose capsules were filled with 300 mg powder. Placebo was prepared in the same manner using maltodextrin. Patients were suggested to take 3 pills a day. Blood samples were collected at the initial and the final day for thyroid stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (Anti-Tg) and C-reactive protein (CRP) analysis. Nodule sizes were also measured at the beginning and at the end of the trial with ultrasonography to identify the changes and effectiveness of dill dosage forms.

After 90 days in the study, the status of TSH, fT3, fT4, anti-TPO and CRP levels were examined in the group with and without Anethum graveolens L..

Again, after the study, the size of thyroid nodules was evaluated in the group who received and did not receive Anethum graveolens L. by ultrasonography.

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Key information

Conditions

Thyroid Nodule Endocrine Gland Neoplasms Endocrine System Diseases Goiter Goiter, Nodular Head and Neck Neoplasms Neoplasms Neoplasms by Site Thyroid Diseases Thyroid Neoplasms Thyroiditis

Age range

18 year–76 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sabahattin Destek

Fatih, Istanbul, 34093, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • To have multi-nodular goiter,
  • To be a benign result in fine needle aspiration biopsy,
  • Euthyroid must be sick,
  • Must be sick over the age of 18,
  • To accept the research.

Exclusion criteria

  • Thyroid function tests non-euthyroid individuals,
  • To have a malignant result in thyroid biopsy,
  • Not giving approval,
  • To be renal failure,
  • Benign pregnant,
  • Taking blood thinning drugs

Treatment and study plan

Giving dill by mouth capsule to the study group and placebo capsule by mouth to the control group.

Dietary Supplement

Tests from intravenous blood: TSH, fT3, fT4, anti-TPO, Anti-Tg, CRP

Other names: Taking blood from the arm intravenously at the beginning and end of the study and looking for thyroid hormones from this blood.

Primary outcomes

  1. Comparison of thyroid stimulating hormone (TSH) between groups

    Time frame: 90 days

    At the beginning and at the end of the study, the levels of serum TSH were measured and statistically compared in groups given Anethum graveolens L. and placebo.

  2. Comparison of free triiodothyronine (fT3) between groups

    Time frame: 90 days

    At the beginning and at the end of the study, the levels of serum fT3 were measured and statistically compared in groups given Anethum graveolens L. and placebo.

  3. Comparison of free thyroxine (fT4) between groups

    Time frame: 90 days

    At the beginning and at the end of the study, the levels of serum fT4 were measured and statistically compared in groups given Anethum graveolens L. and placebo.

  4. Comparison of anti-thyroid peroxidase (anti-TPO) between groups

    Time frame: 90 days

    At the beginning and at the end of the study, the levels of anti-TPO were measured and statistically compared in groups given Anethum graveolens L. and placebo.

  5. Comparison of anti-thyroglobulin (Anti-Tg) between groups

    Time frame: 90 days

    At the beginning and at the end of the study, the levels of serum Anti-Tg were measured and statistically compared in groups given Anethum graveolens L. and placebo.

  6. Comparison of C-reactive protein (CRP) between groups

    Time frame: 90 days

    At the beginning and at the end of the study, the levels of serum CRP were measured and statistically compared in groups given Anethum graveolens L. and placebo.

  7. Comparison of ultrasound and thyroid nodule sizes between groups

    Time frame: 90 days

    At the beginning and end of the study, thyroid nodule sizes (mm) were measured and statistically compared in groups given Anethum graveolens L. and placebo.

Sponsors and collaborators

Lead sponsor

Bezmialem Vakif University

Other

Registry information

Official study title

Randomized Placebo Controlled Clinical Study of Anethum Graveolens L. (Dill) in Thyroiditis and Nodular Goiter Patients

Acronym: Dill

Important dates

Study start
2019
Primary completion
2019
Study completion
2020
First posted
Jul 23, 2020
Registry last updated
Jul 23, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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