Effect of Digene Total (Buffered Pantoprazole) on 24 Hour Gastric Potential Hydrogen (pH) in Patients From Acid Peptic Disorder After Single and Repeated Dosing.

Inclusion criteria

• Adult subjects (18-65 years) suffering from acid peptic disorder (APD), diagnosed endoscopically (reflux esophagitis, gastritis and peptic ulcer)
• Must voluntarily sign and date an informed consent form, approved by an Independent Ethics Committee (IEC)/ Institutional Review Board (IRB), prior to any study specific procedures.
• If female, subject must be either postmenopausal for at least 1 year, surgically sterile (bilateral tubal ligation, bilateral oophorectomy or hysterectomy), or practicing at least one of the following methods of birth control:

• Total abstinence from sexual intercourse (minimum one completed menstrual cycle)
• A vasectomized partner
• Hormonal contraceptives (oral, parenteral or transdermal) for at least 3 months prior to study drug administration.
• Intrauterine device (IUD)
• Double barrier method (condoms, contraceptive sponge, diaphragm or vaginal ring with spermicidal jellies or creams)

Exclusion criteria

• Subjects with concurrent gastrointestinal diseases, gastric surgery, perforation or bleeding
• Subjects who have a history of use of any antisecretory drug within past 7 days prior study Day 0
• Subjects with cardiac, neurological, renal or hepatic dysfunction
• Past history of significant sensitivity or contraindication to study drug
• Pregnant or breast-feeding female
• Any condition that, in the opinion of the Investigator, does not justify the subject's inclusion for the study