Aarhus University, Department for Public Health
Aarhus, Jutland, 8000, Denmark
Location status: Recruiting
Recruiting
NCT Number: NCT07115849
Effect of Different Sex Hormone Profiles for the Response to Physical Training
The aim of the project is to elucidate the impact of diverse sex hormone profiles on the adaptability of muscle mass to physical training. Additionally, the project aims to investigate secondary effects on adipose tissue, tendons, and other physiological parameters associated with physical function.
Recruiting
Interested in participating?
Request InfoKey information
Age range
18 year–35 year
Sex eligibility
Female
Study type
Interventional
Phase
Not applicable
Primary location
About this study
The human study is designed as a prospective study where 3 groups with different sex hormonal profiles are followed in parallel in 4 months and tested before, during (2 months) and after 4 months of physical training intervention. The three groups include a control group with regular menstrual bleeding and two groups who have an altered sex hormonal profile due to use of either IUD (containing the progestin levonorgestrel) or mini pills (containing the progestin desogestrel). Before and after the training period the following will be measured/collected: Body composition, Dietary intake, Physical Activity Level, Blood, Urine, Muscle Tissue, Adipose Tissue, Aerobic capacity in bike test, Strength and muscle function tests, and questionnaires about diet and physical activity.
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- BMI 19-25
Exclusion criteria
- Training more than 2 times per week
- Smoking
- Pregnancy
- Taking any medications known to affect the outcome parameters
Treatment and study plan
physical training
BehavioralAerobic and resistance training three times per week. Two supervised training sessions.
Primary outcomes
-
Muscle mass
Time frame: 4 months
Muscle mass measured by DXA
-
Fat free mass
Time frame: 4 months
Fat free mass measured by DXA
Secondary outcomes
-
Muscle fiber type measured by histochemical staining
Time frame: 4 months
Muscle fiber type measured by histochemical staining
-
Protein expression in skeletal muscle tissue
Time frame: 4 months
Expression of Muscle protein signaling markers for muscle protein degradation and synthesis pathways
-
Adipose tissue sex hormone receptors
Time frame: 4 months
Adipose tissue sex hormone receptors
-
Resting metabolic rate
Time frame: 4 months
Resting metabolic rate measured via indirect calorimetry
-
Maximal oxygen uptake
Time frame: 4 months
Maximal oxygen uptake
-
Muscle strength
Time frame: 4 months
Muscle strength (arm and finger strength)
-
Appetite regulatory markers
Time frame: 4 months
Leptin, Ghrelin, CCK, GLP-1
-
Lipid profile
Time frame: 4 months
Lipid profile
-
Muscle fiber cross sectional area
Time frame: 4 months
Muscle fiber cross sectional area measured by histochemical stainings
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
University of Aarhus
Other
Registry information
Important dates
- Study start
- 2025
- Primary completion
- 2026
- Study completion
- 2028
- First posted
- Aug 11, 2025
- Registry last updated
- Mar 2, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Related clinical trials
Published trials that share one or more normalized conditions with this study.
Not Yet Recruiting
Investigating the Effects of Time-of-day and Menstrual Cycle Phase (Low and High Progesterone) on Female's Cognitive and Strength Performance
NCT07399847
Circadian Rhythm, Eumenorrhea
View Trial Details
Enrolling by Invitation
Bone Metabolism in Premenopausal Exercising Women
NCT06961773
Bone Metabolism, Contraception
Madrid, Comunity of Madrid, Spain
View Trial Details
Recruiting
Quality of Life During Different Regimens of Combined Hormonal Contraceptives in Women of Reproductive Age
NCT06918873
Hormonal Contraception, Mental Disorders
Pavia, Italy
View Trial Details
Recruiting
Oxytocin and Reward Processing in Women
NCT06222749
Behavior, Behavior, Animal
Tübingen, Baden-Wurttemberg, Germany
View Trial Details