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Completed

NCT Number: NCT07355816

Effect of Different Root Canal Disinfection Procedures on Postoperative Pain

This clinical study evaluated the effects of different root canal disinfection procedures on postoperative pain. Patients requiring root canal treatment received one of several disinfection methods. Postoperative pain was assessed at 6,24, 48, 72 hours and on the 7th day using a standard pain scale. The aim of the study was to identify which method resulted in the least discomfort. Participation involved a single treatment session and short-term follow-up for pain measurement.

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Key information

Conditions

Pain, Postoperative Neurologic Manifestations Pain Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry, Cumhuriyet University, Sivas

Sivas, 58000, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Systemically healthy individuals between the ages of 18 and 65,
  • Adequate mouth opening,
  • Asymptomatic devitaled mandibular premolar with a single root and single canal,
  • Negative response to cold and electric pulp tests and no bleeding at the pulp chamber opening,
  • Able to provide rubber dam isolation,
  • Presence of opposing teeth.

Exclusion criteria

  • Presence of mental or psychiatric disorders,
  • Allergic diseases,
  • Use of painkillers within 12 hours or antibiotics within 1 week before the procedure,
  • Swelling, palpation/percussion pain, or sinus tract before treatment,
  • Presence of a periodontal pocket greater than 3 mm in diameter on the involved tooth,
  • Presence of a periapical radiolucency greater than 5 mm in diameter associated with the involved tooth,
  • Initiation of root canal treatment,
  • Irreparable material loss, root fracture, or crack,
  • Severe mobility,
  • Open apex,
  • Severe root canal calcification,
  • Internal or external resorption,
  • Bruxism,
  • Complaints of pain elsewhere in the mouth or in a tooth,
  • Being pregnant or breastfeeding.

Treatment and study plan

Conventional Needle Irrigation

Procedure

Root canals will be irrigated using a conventional syringe and needle technique with standard irrigant solutions. This method relies solely on manual delivery without activation devices.

Passive Ultrasonic Irrigation

Procedure

Root canals will be irrigated using passive ultrasonic activation, which uses ultrasonic energy to improve irrigant effectiveness and reduce microbial load beyond manual techniques.

Sonic Irrigation

Procedure

Root canals will be irrigated using a sonic activation device (e.g., EndoActivator) to enhance irrigant penetration and bacterial elimination compared to conventional irrigation.

KTP Laser Disinfection

Procedure

Root canals will be disinfected using a KTP laser following standard irrigation protocols. Laser application aims to provide enhanced antimicrobial effects not achievable with conventional or activated irrigation methods.

Primary outcomes

  1. Postoperative Pain Intensity

    Time frame: 6, 12, 24, 48, and 72 hours after root canal treatment

    Postoperative pain intensity assessed using the Visual Analog Scale (VAS), ranging from 0 to 100, where 0 indicates no pain and 100 indicates the worst pain imaginable; higher scores indicate greater pain severity

Sponsors and collaborators

Lead sponsor

Cumhuriyet University

Other

Registry information

Official study title

Effect of Different Root Canal Disinfection Procedures on Postoperative Pain: A One-Week Follow-Up Clinical Study

Acronym: EDRCD-PP

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jan 21, 2026
Registry last updated
Jan 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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