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NCT Number: NCT07121348

Effect of Different NanoScaffolds on Pulp Regeneration in Non-Vital Immature Permanent Teeth (Randomized Clinical Trial)

the clinical trial aims to evaluate efficency of different scaffolds in cases of regeneration

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Necrotic Immature Permanent Incisors

Age range

9 year–18 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry,Tanta University

Tanta, Gharbia Governorate, Egypt

About this study

The aim of this study is to evaluate the clinical and radiographic outcome of regenerative endodontic procedures in immature non-vital permanent teeth using different nanoscaffolds (Platelet-rich fibrin, Mesoporous silica nanoparticles, Hyaluronic acid nanoparticles, Pomegranate nanoparticles)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

• Patients free from any systemic diseases that may interfer with the normal healing process.

  • Maxillary traumatized or cariously exposed non-vital immature anterior teeth.
  • Teeth don't need for post and core as a final restoration.
  • Radiographic evidence of an apical opening width more than 2 mm with or without periapical radiolucency.
  • Teeth without anatomical variations

Exclusion criteria

• Immunocompromised patients

  • Teeth with previous endodontic treatment.
  • Teeth with internal or external resorption
  • Radiographic evidence of root fracture.
  • Lack of patient and parent cooperation.
  • Presence of periodontal pocket depth more than 4 mm.

Treatment and study plan

Platelet Rich Fibrin

Procedure

platelet rich fibrin is obtained by removing the middle layer from a centrifuged blood sample and is rich with platelets that plays an important role in tissue regeneration mesoporous silica nanoparticles are high surface area and excellent biocompatibility and enhance the outcome hyalurnic acid nanoparticles are high water capacity and involved in cell proliferation and adhesion and help in tissue regeneration pomegranate nanoparticles has anti-inflammatory and antibacterial effect and also help in tissue proliferation and regeneration

Other names: mesoporous silica nanoparticles, hyaluronic acid nanoparticles, pomegranate (punica granatum) nanoparticles

Primary outcomes

  1. apical closure assessed radiographically

    Time frame: 12 months after treatment

    radiographic evaluation of apical closure as reduction or elimination of the apical opening of the root

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Acronym: Regeneration

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Aug 13, 2025
Registry last updated
Aug 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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