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Completed

NCT Number: NCT05319951

Effect of Different Liquids Intake in Vasovagal Reaction After Whole Blood Donation

we compared the effect of 3 different kinds of liquids (water, Oral Rehydration Salt 3 and white granulated sugar water) intake in Vasovagal Reaction After Whole Blood Donation

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Key information

Conditions

Blood Donation

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Guangzhou Blood Center

Guangzhou, Guangdong, 510095, China

About this study

Vasovagal reaction is the most common type of blood donation reaction. The main cause of this reaction is the decrease of blood volume. Therefore, fluid supplement before blood donation has been proved to be effective in preventing the vagal reaction after blood donation. It was proved that isotonic (sugar & salt) drink intake before blood donation had a significant effect on reducing vasovagal reaction.

However, in 2002, WHO recommended the new reduced osmolarity rehydration formula with better taste. Oral Rehydration Salt 3 has been produced according to WHO formula with standard ingredient and easy to prepare. In addition, in Guangdong culture, sugar water is regarded as a tonic, more easily accepted. So, the aim of our study was to compare the effects of 500 ml water with Oral Rehydration Salt 3, white granulated sugar and conventional recommended water intake prior to blood donation on blood donation reaction after whole blood donation, in order to understand the effect of different liquid supplement on blood donation reaction and the willingness of blood donation again.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All blood donors donated whole blood in Guangzhou Blood Center during study.

-

Exclusion criteria

Blood donors who were deferral by blood screening result and other situations.

-

Treatment and study plan

Oral Rehydration Salts power (iii)

Drug

Dissolve 2 packs of Oral Rehydration Salts Power (iii) (5.125g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.

Other names: Sichuan Emeishan Pharmaceutical Co., Ltd. 20210402 5100621103491

water with white granulated sugar

Dietary Supplement

Dissolve 2 packs of Taikoo white granulated sugar (5g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.

Water

Dietary Supplement

Recommend the subjects to drink up 500ml water in 20 minutes prior to donation.

Primary outcomes

  1. vasovagal reaction rate

    Time frame: 1-3days

    vasovagal reaction rate in three groups

Secondary outcomes

  1. rate of willingness to donate blood again

    Time frame: 3days

    rate of willingness to donate blood again in three groups

Sponsors and collaborators

Lead sponsor

Guangzhou Blood Center

Other Gov

Registry information

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Apr 11, 2022
Registry last updated
Oct 3, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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