Effect of Different Biomimetic Materials on White Spot Lesions in Enamel

This study will be conducted to evaluate: 1- The remineralizing effect of different biomimetic materials (Zinc carbonate hydroxyapatite nanoparticles, Poly-amido amine (PAMAM) and bioactive glass nanoparticles) on white spot lesions in enamel. 2- The clinical efficacy of these agents on disappearance of these white spots.

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Key information

Conditions

White Spot Lesion

Age range

15 year–25 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of dental medicine for girls branch of Alazhar University

Cairo, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Total of 21 patients enrolled in this study will be selected having at least 4 teeth (one on each quadrant) which will be extracted for orthodontic treatment.
These patients will be selected according to age groups between 15-25 years old
good oral hygiene
free of destroying habits for dental tissues

Exclusion criteria

Bruxism
soft drinks consumption
acid regurgitation, etc.).
Selected teeth having any cracks, malformations, dysplasia or caries.

Treatment and study plan

Time of assessment

Other

Immediate and after one month and after two months

Primary outcomes

change in remineralization from base line to time limit

Time frame: Immediate and one month and two months

Change in its density in digital xray
changes of appearance from base line photograph to time limit

Time frame: Immediate and one month and two months

White spots disappear on digital photography

Sponsors and collaborators

Lead sponsor

Benha University

Other

Registry information

Important dates

Study start: 2021
Primary completion: 2021
Study completion: 2021
First posted: Aug 11, 2021
Registry last updated: Oct 7, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed