Effect of Diet on the Microbiota / Endoccanabinoidome Axis in Response to Physical Activity

Both the endocannabinoid system and the microbiome are highly conditioned by nutrition and physical activity, and have an interdependent, bidirectional relationship. We suggest studying the interleaving between the endocannabinoidome-microbiome axis and host metabolism under the combined effect of a diet and physical activity. More specificly, we will study the link between the impact of the diet on the intestinal microbiome and the endocannabinoid reaction after intense exercise.

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Key information

Conditions

Diet Habit Activity, Motor Behavior Behavior, Animal Communicable Diseases Disease Attributes Feeding Behavior Infections Microbial Colonization Motor Activity Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

20 year–30 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Institut sur la nutrition et les aliments fonctionnels

Québec, G1V0A6, Canada

About this study

Aims of the study are to compare the impacts of two short 7-day contrasted nutritional interventions (the Mediterranean diet (MED) and the Canadian diet (CAN)) on blood metabolites (endocannabinoids) after a maximal aerobic test. A 3 weeks washout between the two diets is planned. Gut microbiome at each test will also be evaluated.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

women
20-30 years old
healthy
jogging >1h/week and >3h/week of physical activity
bmi 18.5-25

Exclusion criteria

postmenopausal, pregnancy or lactation
pathology or medication
smoking
more than 7 alcohol consumption/week
food allergy, food intolerance or food aversion
important weight change in the last 6 months
antibiotics in the last 3 months
night worker
pathologies

Treatment and study plan

3 maximal aerobic tests

Other

Maximal aerobic tests will be performed before diet intervention, after the first diet and after the second diet

Primary outcomes

Endocannabinoid level post physical activity

Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Laval University

Other

Registry information

Official study title

Effect of Dietary Composition on the Gut Microbiota / Endocannabinoidome Axis in Response to Maximal Aerobic Exercise

Acronym: PerOME

Important dates

Study start: 2019
Primary completion: 2019
Study completion: 2019
First posted: Feb 23, 2021
Registry last updated: Feb 23, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed