Effect of Dexmedetomidine on the Inflammatory Response After One-lung Ventilation

The postoperative inflammatory response is significant in lung resection surgery because of major operation and one-lung ventilation. Dexmedetomidine has been shown to reduce pro-inflammatory cytokine levels and improve clinical outcomes. The aim of this study was to determine the effects of dexmedetomidine on inflammatory responses after lung resection surgery.

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Key information

Conditions

Lung Cancer Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

20 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul St.Mary's Hospital

Seoul, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

elective video-assisted thoracoscopic surgery (VATS) lobectomy
20 < age < 75
American Society of Anesthesiologists (ASA) classification I~II

Exclusion criteria

preoperative inflammation (CRP>10ng/#, WBC>10,000/mm3, body temperature >38#)
steroid administration within 1 month
hematologic / autoimmune disease
congestive heart failure (NYHA class III~IV) or significant arrhythmia
severe obstructive / restrictive pulmonary disease
previous history of thoracic surgery

Treatment and study plan

Dexmedetomidine

Drug

The study drug for each group was administered from the time immediately after induction of anesthesia until the end of the surgery.

Primary outcomes

Interleukin (IL)-6

Time frame: 24 hours after surgery

Blood samples were collected from the antecubital vein

Sponsors and collaborators

Lead sponsor

Seoul St. Mary's Hospital

Other

Registry information

Official study title

Effect of Dexmedetomidine on the Inflammatory Response in Patients Undergoing Lung Resection Surgery

Important dates

Study start: 2018
Primary completion: 2019
Study completion: 2019
First posted: Jul 5, 2019
Registry last updated: Jul 5, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed