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Completed

NCT Number: NCT02643017

Effect of Dexmedetomidine on Postoperative Cognitive Function in Patients Undergoing Shoulder Arthroscopy With Beach Chair Position Under Desflurane Anesthesia

Investigate the effects of dexmedetomidine on postoperative cognitive function in patients undergoing shoulder arthroscopy with beach chair position under desflurane anesthesia.

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Key information

Conditions

Rotator Cuff Tear Rotator Cuff Injuries Rupture Shoulder Injuries Tendon Injuries Wounds and Injuries

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine

Seoul, 03722, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergoing shoulder arthroscopic surgery with beach chair position

Exclusion criteria

  • Patients with respiratory disease
  • Patients with cardiac disease
  • Patients with cerebrovascular disease
  • patients with uncontrolled hypertension
  • Patients with dementia
  • Patients with psychiatric disease

Treatment and study plan

Dexmedetomidine

Drug

Administration of dexmedetomidine at a rate 0.6 ug/kg/hr during surgery.

normal saline

Drug

Administration of same amount of dexmedetomidine at a rate 0.6 ug/kg/hr during surgery.

Primary outcomes

  1. Number of patients with postoperative cognitive decline assessed by mini-mental state examination

    Time frame: from 1 day before surgery to postoperative 1 day

    to compare cognitive decline after surgery between control and dexmedetomidine group with mini-mental state examination.

  2. Number of patients with postoperative cognitive decline assessed by a battery of psychometric test

    Time frame: from 1 day before surgery to postoperative 1 day

    to compare cognitive decline after surgery between control and dexmedetomidine group with a battery of psychometric test. The battery consists of copy geometric form test, two-dimensional model test, grooved pegboard test, colored block design test, puzzle test, clock drawing test.

Secondary outcomes

  1. Number of patients with increase of S100ß protein after surgery assessed by ELISA assay with blood of patients

    Time frame: from 5 min after induction of anesthesia to an 1 hour after surgery

    S100ß protein is the biologic marker for neuroinflammation

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Important dates

Study start
2015
Primary completion
2018
Study completion
2018
First posted
Dec 30, 2015
Registry last updated
Jan 25, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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