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OpenTrials
Completed

NCT Number: NCT05778305

Effect of Dexmedetomidine on Left Ventricular Function in Coronary Artery Bypass Graft Surgery Outcome

50 patients of both sexes undergoing elective CABG surgery will be randomly divided into 2 groups, study group (Dex) group and control group (C) to determine the effect of dexmedetomidine on the peri-operative hemodynamic changes during CABG surgery.

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Key information

Conditions

Effect of Drug in CABAG Patients

Age range

30 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Ain Shams University

Cairo, Abassia, Egypt

About this study

The effect of dexmedetomidine during CABG surgery is studied regarding Ventricular function, pre bypass and post bypass using the transoeophageal echo (TEE), post-operative by transthoracic echocardiography (TTE) on day of surgery and after extubation.

Incidence of intraoperative and post operative ischemia and arrhythmias using Electrocardiogram (ECG) as well as the length of ICU and hospital stay.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • undergoing elective CABG surgery

Exclusion criteria

  • Patient refusal
  • Dementia patients
  • Poor ventricular function with ejection fraction below 40%
  • Asthmatic patients
  • Uncontrolled diabetic patients with HbA1c above 8
  • Combined surgeries (CABG+ valves)
  • Emergency surgeries.
  • Pre-existing arrhythmia
  • Patients with renal impairment
  • Patients with hepatic impairment
  • Patients with heart block
  • Off-pump CABG

Treatment and study plan

Dexmedetomidine

Drug

a central sympatholytic drug

Other names: precedex

Normal Saline

Other

saline is given to control group

Other names: saline

Primary outcomes

  1. Intra-operative ventricular function.

    Time frame: Intraoperative

    global systolic function Ejection Fraction by TEE intraoperative

  2. post-operative ventricular function.

    Time frame: Up to 24 hours postoperative

    global systolic function Ejection Fraction by TTE postoperative

Secondary outcomes

  1. hemodynamics

    Time frame: Immediate postoperative and up to 24 hours postoperative

    Heart Rate (beat/minute),

  2. hemodynamics

    Time frame: Immediate postoperative and up to 24 hours postoperative

    Mean arterial blood pressure (mmHg)

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Effect of Dexmedetomidine on Stress-induced Changes in Hemodynamics and Left Ventricular Function in Coronary Artery Bypass Graft Surgery Outcome

Acronym: CABAG

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Mar 21, 2023
Registry last updated
Oct 9, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.