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Completed

NCT Number: NCT02648958

Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Lower Extremity Operations

Ischemia reperfusion injury causes the release of free oxygen radicals. The selective alpha2-receptor agonist, dexmedetomidine, has an inhibitory effect on inflammatory responses during ischemic injury. The aim of this study is to evaluate the effect of dexmedetomidine on inflammatory responses during ischemia-reperfusion injury in skeletal muscle.

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Key information

Conditions

Arthroplasty, Replacement

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Severance hospital

Seoul, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • American Society Anesthesiologists classification I-III

Exclusion criteria

  • use of antioxidants clinically significant cardiovascular, renal, or hepatic diseases heart block greater than the first degree

Treatment and study plan

Dexmedetomidine

Drug

The dexmedetomidine group received the dexmedetomidine infusion at a rate of 0.4mg/kg/h after a loading dose of 0.5mg/kg for 10 minutes.

Other names: precedex

normal saline

Drug

The control group received the normal saline infusion

Primary outcomes

  1. changes of malondialdehyde (μmol/L)

    Time frame: up to 1 day

Secondary outcomes

  1. changes of interleukin-6 (pg/ml)

    Time frame: up to 1 day

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Official study title

Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Unilateral Total Knee Replacement - a Randomized, Controlled Trial

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Jan 7, 2016
Registry last updated
Jun 13, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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