Effect of Desflurane v/s Propofol on th… | Clinical Trial

Key information

Conditions

Propofol Target-controlled Infusion Desflurane Optic Nerve Sheath Diameter

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

AIIMS

Raebareli, Uttar Pradesh, 229405, India

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient aged 18-60 years ASA grade I or II scheduled for elective laparoscopic cholecystectomy

Exclusion criteria

patients with ophthalmological and cerebrovascular diseases, systemic infections, psychiatric disorders, pregnancy, Intracranial space occupying lesion, abnormal liver/kidney functions prior myocardial infarction.

Treatment and study plan

Desflurane

Drug

In the D group, anesthesia was maintained with oxygen/air (40:60), desflurane, fentanyl and vecuronium

Propofol (Group P)

Drug

In the P group, anesthesia was maintained with oxygen/air (40:60), propofol infusion @50 to 100mcg/kg/min, fentanyl and Vecuronium

Primary outcomes

Optic nerve sheath diameter(ONSD)

Time frame: before induction, introperative period for every 10 minutes

ONSD will be measured in the operation thetaer

Sponsors and collaborators

Lead sponsor

All India Institute of Medical Sciences

Other

Collaborators

All India Institute of Medical Sciences, Raebareli, UP

Registry information

Official study title

Effect of Desflurane v/s Propofol on the Optic Nerve Sheath Diameter in Patients Undergoing Laparoscopic Cholecystectomy

Acronym: ONSD

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Jan 22, 2026
Registry last updated: Jan 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed