Skip to main content
OpenTrials
Completed

NCT Number: NCT04009564

Effect of Date Seeds Coffee on Mood and Cognitive Performance

Limited utilizations of date seeds have previously been explored, and so previously wastage has often been the normality. However, research now indicates that several fruit seeds contain higher concentrations of beneficial total phytochemicals within their seeds in comparison to the flesh. As well as high nutritional values of date seeds for fibre, protein and micronutrients, this increased phytochemical content has been proven to be true for date seeds, with mainly phenolic acids (24.6 g k GAE) 3 and total flavonoids (3.67 g k RE). With the seeds presently being used to produce new coffee products, it raises questions on whether consumption of date seeds can alter mood and cognitive behaviour and therefore research into investigate the acute effect of date seeds coffee on mood and cognitive function on healthy young volunteers. However, to the best of the research team knowledge, this is the first human trial to investigate these effects.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

NU-Food Research Facility

Newcastle upon Tyne, Tyne and Wear, NE1 7RU, United Kingdom

About this study

Introduction

Seeds of the date palm (P. dactylifera) are a very rich source of bioactive compounds, thus constituting strong candidates for functional food additives and nutraceuticals. Many promising results were observed when the effect of date flesh and seeds consumption have been studied in animals, for their role as either a protective1 against neurodegenerative 2,4,5 diseases, or as a cure for it 2. Most of the observed effects were attributed to the antioxidant and anti-inflammatory properties in dates flesh and seeds fruit due to it high content of phenolic compounds 3.

Rational For years, date seeds were considered a waste, having no other uses except for feeding animals. However, as has already been demonstrated in other fruits and corresponding seeds, total phytochemical content of the date seeds was higher than in the edible flesh9. Date seeds have also been shown to have an excellent nutritional quality due to high amounts of fibre (676-742 g/kg) 3 depending on variety, considerable amounts of minerals, vitamins, lipids and protein. Additionally, date seeds were shown to be rich in antioxidants containing mainly phenolic acids (24.6 g k Gallic Acid equivalent) 3 and total flavonoids (3.67 g k Rutin Equivalent).

Nowadays, and on sight of the aforementioned findings, date seeds are used to make a new coffee product. This ''coffee alternative'' is commercially available and is becoming more popular.

Although, many studies have demonstrated that date seeds possess high antioxidant activities, due to their high content of flavonoids and phenolic compounds, no human trial has investigated the effect of the consumption of date seeds on humans and especially on mood and cognitive behaviour. Therefore, this study, for the first time, to the best of the research team knowledge will investigate the acute effect of date seeds coffee on mood and cognitive function on healthy young volunteers.

Aim The aim of this study is to investigate the acute effects of a coffee made of date seeds on mood and cognitive performance.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy young volunteers age between 18 to 35

Exclusion criteria

Participants will be ineligible to participate in the study if any of the following apply:

  • Have a BMI above 35kg/m2
  • Smokers or tobacco product consumers which includes electronic cigarettes
  • Are taking any illicit or prescribed drugs.
  • Have a history of, or currently, abuse alcohol
  • Have a history of dyslexia, ADHD, learning difficulties or colour blindness,
  • Females who are pregnant, lactating or seeking to become pregnant, or are at risk of pregnancy as they to do not use birth control measures
  • Have allergies to any food product.

Treatment and study plan

Date coffee

Dietary Supplement

45 g of date seeds coffee in 280 ml of water

Normal coffee

Dietary Supplement

6 g of normal coffee in 280ml of water

Placebo

Dietary Supplement

water, food colouring and coffee flavouring

Primary outcomes

  1. The average of the change in 9 cognitive indexes including: Attentional Intensity, Sustained Attention, Attentional Fluctuation, Memory Retrieval Speed, Cognitive Reaction Time, Working Memory Capacity, Episodic Memory Capacity, Quality of Memory

    Time frame: Change from baseline at 45 minutes post dose and at 90 minutes post dose for each visit

    Cog-track an online set of nine cognitive tests (www.wesnes.com).

Secondary outcomes

  1. Change in Caffeine consumption using caffeine consumption questionnaire

    Time frame: Change form Baseline for each visit only

    A paper based questionnaire developed by Erika Bühler et al., 2014. At the screening visit and on each study day participants will be asked to complete the table in order to build a picture of their individual caffeine habits

  2. Caffeine research Visual Analogue Scales

    Time frame: Change from baseline 45 minutes post dose and at 90 minutes post dose.

    A caffeine research Visual Analogue Scales which comprises of 7 scales (relaxed, alert, jittery, tired, tense, headache and overall mood).

  3. Change in Mood using Bond Lader Visual Analogue Scales

    Time frame: Change from baseline 45 minutes post dose and at 90 minutes post dose.

    This widely used set of 16 100 mm VASs yields three extensively validated factor scores: alertness, calmness and contentment.

Sponsors and collaborators

Lead sponsor

Newcastle University

Other

Registry information

Official study title

Investigating the Acute Effects of Mood and Cognitive Performance Following the Administration of a Coffee Made of Date Seeds on Healthy Young Volunteers.

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Jul 5, 2019
Registry last updated
Aug 31, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.