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OpenTrials
Completed

NCT Number: NCT04706806

Effect of Daily Vinegar Ingestion for Four Weeks on Mood State in Healthy College Students

The objective of this research is to record mood states and depression levels in healthy college students before and after 4 weeks of daily vinegar ingestion.

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Key information

Conditions

Mood Behavior Behavioral Symptoms Depression

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Arizona State University

Phoenix, Arizona, 85004, United States

About this study

Recent research suggests that fruit and vegetable intake is inversely associated with mood states and depression. Although the mechanism is not known, increased gut fermentation is suspected as changes in gut tryptophan metabolism was noted in these trials. Tryptophan is the precursor to serotonin, the neurotransmitter associated with improved mood state, but other metabolites of tryptophan have been associated with mental wellbeing as well. The main ingredient of vinegar, acetic acid, is the most common metabolite produced during gut fermentation of dietary fiber (mainly from fruits and vegetables) and can also be expected to influence the gut microbiome. It has been reported that vinegar ingestion is linked to a change in tryptophan metabolism in healthy adults consuming vinegar daily for 8 weeks. This study will explore the impact of vinegar ingestion on mood states.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • college student, non-athlete, no chronic health condition

Exclusion criteria

  • vegetarians or others adhering to special diet, body mass index >30 kg/m2, pregnancy/lactation, unwilling to ingest vinegar

Treatment and study plan

apple cider vinegar

Dietary Supplement

2 tablespoons diluted in water taken twice daily with meals

Other names: apple cider vinegar (Bragg Live Food Products, LLC)

Vinegar pill

Dietary Supplement

one pill taken daily

Other names: Nature's Bounty Apple Cider Vinegar pills

Primary outcomes

  1. mood state

    Time frame: change from baseline at day 28

    Profile of Mood States (POMS) questionnaire score

  2. depression

    Time frame: change from baseline at day 28

    Center for Epidemiologic Studies Depression Scale (CES-D)

Sponsors and collaborators

Lead sponsor

Arizona State University

Other

Registry information

Acronym: VIN2020

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Jan 13, 2021
Registry last updated
Jan 13, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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