Effect of Daily Low Dose Aspirin on Exhaled Inflammatory Mediators in Normal Subjects

Hypothesis: Low dose aspirin does not change exhaled inflammatory breath mediators in normal subjects.

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Key information

Conditions

Healthy

Age range

18 year–95 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Asthma Research Center, Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

About this study

Aim:

To study the effect of low dose aspirin on exhaled breath inflammatory mediators
To compare the change to that seen in diseased states such as asthma and Lymphangioleiomyomatosis (LAM)

We will interview healthy volunteers to confirm that they do not have any major underlying medical conditions such as heart disease, diabetes, stroke and bleeding disorders. We will collect breath condensate before and after two weeks of low dose over the counter enteric coated aspirin 81 mg/day therapy. Side effects are extremely rare at this dose, but include bleeding, heart burn and allergic reaction.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

healthy adults

Exclusion criteria

any underlying major medical conditions such as heart disease, hypertension, stroke, diabetes, bleeding disorders

Treatment and study plan

Aspirin

Drug

81 mg orally daily for two weeks

Primary outcomes

Change in Exhaled Inflammatory Mediator Levels

Time frame: baseline and 6 months

Descriptive statistics

Sponsors and collaborators

Lead sponsor

Brigham and Women's Hospital

Other

Registry information

Important dates

Study start: 2009
Primary completion: 2009
Study completion: 2009
First posted: May 12, 2009
Registry last updated: Sep 25, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed