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Completed

NCT Number: NCT01489592

Effect of Curcumin on Iron Metabolism in Healthy Volunteer

The purpose of this study is to determine the impact of curcumin, administrated orally, on iron metabolism in healthy volunteers. Iron metabolism will be describe by hepcidin expression that the investigators observed in vitro and serum hepcidin levels.

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Key information

Conditions

Healthy Volunteers

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 2

Primary location

Centre d'Investigation Clinique (CIC) , 2 rue Henri Le Guilloux , CHU Pontchaillou

Rennes, 35000, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Body mass index between 18 et 25 Kg/m²
  • Non smoker
  • No swallowing disorders
  • Normal clinical exam
  • Normal ECG
  • Normal values for routine biological tests : serum iron, transferrin saturation,, hemogram ferritin, C Reactive Protein, AST, ALT, HDL and LDL cholesterol, triglycerides
  • No C282Y mutation within the HFE gene
  • Affiliation to social security
  • Written informed consent obtained

Exclusion criteria

  • Chronic or evolutive disease
  • Infection during the 7 days before each sequence
  • Drug or alcohol (>30g) abuse
  • Current treatment
  • Known food allergy
  • stay at altitude (> 1500m) in 2 months
  • Positive serology for hepatitis B or C virus or HIV.
  • Transfusion or blood donation during the last three months.
  • Exclusion period on the healthy volunteer National File.

Treatment and study plan

curcuma longa

Drug

oral administration of 6 grams of curcumin

Primary outcomes

  1. Maximal variation of serum hepcidin level after oral administration of curcumin

    Time frame: within 48 hours after administration of curcumin

Secondary outcomes

  1. Plasmatic iron bioavailability

    Time frame: 30min, 1H, 2H, 3H, 4H, 6H, 8H, 12H, 24H et 48H

    Iron, ferritin, transferrin, transferrin saturation

  2. Evaluation of the inhibitory activity of volunteers's serum on hepcidin expression by hepatocytes

    Time frame: 30min, 1h, 2h, 3h, 4h, 6h, 8h, 12h, 24h

    In vitro:

    • the coculture model that we previously developed to analyze endogenous hepcidin expression, and
    • human hepatic cells line (HepG2) stimulated or not by IL-6 which governs the STAT3 pathway, transfected with gene reporter constructs containing hepcidin promoter.

Sponsors and collaborators

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Other Gov

Registry information

Acronym: CURHEP

Important dates

Study start
2011
Primary completion
2011
Study completion
2012
First posted
Dec 9, 2011
Registry last updated
Aug 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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